Cargando…
Multi‐omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer
Prostate cancer is the most commonly diagnosed malignancy and the third leading cause of cancer deaths. GWAS have identified variants associated with prostate cancer susceptibility; however, mechanistic and functional validation of these mutations is lacking. We used CRISPR‐Cas9 genome editing to in...
Autores principales: | Stentenbach, Maike, Ermer, Judith A, Rudler, Danielle L, Perks, Kara L, Raven, Samuel A, Lee, Richard G, McCubbin, Tim, Marcellin, Esteban, Siira, Stefan J, Rackham, Oliver, Filipovska, Aleksandra |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245041/ https://www.ncbi.nlm.nih.gov/pubmed/37093546 http://dx.doi.org/10.15252/emmm.202317463 |
Ejemplares similares
-
Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation
por: Hughes, Laetitia A., et al.
Publicado: (2023) -
A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance
por: Rossetti, Giulia, et al.
Publicado: (2021) -
Reduced mitochondrial translation prevents diet-induced metabolic dysfunction but not inflammation
por: Perks, Kara L., et al.
Publicado: (2020) -
The FASTK family proteins fine-tune mitochondrial RNA processing
por: Ohkubo, Akira, et al.
Publicado: (2021) -
Fidelity of translation initiation is required for coordinated respiratory complex assembly
por: Rudler, Danielle L., et al.
Publicado: (2019)