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Mutational screens highlight glycosylation as a modulator of colony-stimulating factor 3 receptor (CSF3R) activity

The colony-stimulating factor 3 receptor (CSF3R) controls the growth of neutrophils, the most abundant type of white blood cell. In healthy neutrophils, signaling is dependent on CSF3R binding to its ligand, CSF3. A single amino acid mutation in CSF3R, T618I, instead allows for constitutive, ligand-...

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Detalles Bibliográficos
Autores principales:	Hollander, Michael J., Malaker, Stacy A., Riley, Nicholas M., Perez, Idalia, Abney, Nayla M., Gray, Melissa A., Maxson, Julia E., Cochran, Jennifer R., Bertozzi, Carolyn R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245049/ https://www.ncbi.nlm.nih.gov/pubmed/37116708 http://dx.doi.org/10.1016/j.jbc.2023.104755

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