Cargando…
Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine
Skin tissue engineering possesses great promise in providing successful wound injury and tissue loss treatments that current methods cannot treat or achieve a satisfactory clinical outcome. A major field direction is exploring bioscaffolds with multifunctional properties to enhance biological perfor...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245056/ https://www.ncbi.nlm.nih.gov/pubmed/37292094 http://dx.doi.org/10.3389/fbioe.2023.1160577 |
_version_ | 1785054780272410624 |
---|---|
author | Fadilah, Nur Izzah Md Riha, Shaima Maliha Mazlan, Zawani Wen, Adzim Poh Yuen Hao, Looi Qi Joseph, Blessy Maarof, Manira Thomas, Sabu Motta, Antonella Fauzi, Mh Busra |
author_facet | Fadilah, Nur Izzah Md Riha, Shaima Maliha Mazlan, Zawani Wen, Adzim Poh Yuen Hao, Looi Qi Joseph, Blessy Maarof, Manira Thomas, Sabu Motta, Antonella Fauzi, Mh Busra |
author_sort | Fadilah, Nur Izzah Md |
collection | PubMed |
description | Skin tissue engineering possesses great promise in providing successful wound injury and tissue loss treatments that current methods cannot treat or achieve a satisfactory clinical outcome. A major field direction is exploring bioscaffolds with multifunctional properties to enhance biological performance and expedite complex skin tissue regeneration. Multifunctional bioscaffolds are three-dimensional (3D) constructs manufactured from natural and synthetic biomaterials using cutting-edge tissue fabrication techniques incorporated with cells, growth factors, secretomes, antibacterial compounds, and bioactive molecules. It offers a physical, chemical, and biological environment with a biomimetic framework to direct cells toward higher-order tissue regeneration during wound healing. Multifunctional bioscaffolds are a promising possibility for skin regeneration because of the variety of structures they provide and the capacity to customise the chemistry of their surfaces, which allows for the regulated distribution of bioactive chemicals or cells. Meanwhile, the current gap is through advanced fabrication techniques such as computational designing, electrospinning, and 3D bioprinting to fabricate multifunctional scaffolds with long-term safety. This review stipulates the wound healing processes used by commercially available engineered skin replacements (ESS), highlighting the demand for a multifunctional, and next-generation ESS replacement as the goals and significance study in tissue engineering and regenerative medicine (TERM). This work also scrutinise the use of multifunctional bioscaffolds in wound healing applications, demonstrating successful biological performance in the in vitro and in vivo animal models. Further, we also provided a comprehensive review in requiring new viewpoints and technological innovations for the clinical application of multifunctional bioscaffolds for wound healing that have been found in the literature in the last 5 years. |
format | Online Article Text |
id | pubmed-10245056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102450562023-06-08 Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine Fadilah, Nur Izzah Md Riha, Shaima Maliha Mazlan, Zawani Wen, Adzim Poh Yuen Hao, Looi Qi Joseph, Blessy Maarof, Manira Thomas, Sabu Motta, Antonella Fauzi, Mh Busra Front Bioeng Biotechnol Bioengineering and Biotechnology Skin tissue engineering possesses great promise in providing successful wound injury and tissue loss treatments that current methods cannot treat or achieve a satisfactory clinical outcome. A major field direction is exploring bioscaffolds with multifunctional properties to enhance biological performance and expedite complex skin tissue regeneration. Multifunctional bioscaffolds are three-dimensional (3D) constructs manufactured from natural and synthetic biomaterials using cutting-edge tissue fabrication techniques incorporated with cells, growth factors, secretomes, antibacterial compounds, and bioactive molecules. It offers a physical, chemical, and biological environment with a biomimetic framework to direct cells toward higher-order tissue regeneration during wound healing. Multifunctional bioscaffolds are a promising possibility for skin regeneration because of the variety of structures they provide and the capacity to customise the chemistry of their surfaces, which allows for the regulated distribution of bioactive chemicals or cells. Meanwhile, the current gap is through advanced fabrication techniques such as computational designing, electrospinning, and 3D bioprinting to fabricate multifunctional scaffolds with long-term safety. This review stipulates the wound healing processes used by commercially available engineered skin replacements (ESS), highlighting the demand for a multifunctional, and next-generation ESS replacement as the goals and significance study in tissue engineering and regenerative medicine (TERM). This work also scrutinise the use of multifunctional bioscaffolds in wound healing applications, demonstrating successful biological performance in the in vitro and in vivo animal models. Further, we also provided a comprehensive review in requiring new viewpoints and technological innovations for the clinical application of multifunctional bioscaffolds for wound healing that have been found in the literature in the last 5 years. Frontiers Media S.A. 2023-05-24 /pmc/articles/PMC10245056/ /pubmed/37292094 http://dx.doi.org/10.3389/fbioe.2023.1160577 Text en Copyright © 2023 Fadilah, Riha, Mazlan, Wen, Hao, Joseph, Maarof, Thomas, Motta and Fauzi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Fadilah, Nur Izzah Md Riha, Shaima Maliha Mazlan, Zawani Wen, Adzim Poh Yuen Hao, Looi Qi Joseph, Blessy Maarof, Manira Thomas, Sabu Motta, Antonella Fauzi, Mh Busra Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine |
title | Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine |
title_full | Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine |
title_fullStr | Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine |
title_full_unstemmed | Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine |
title_short | Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine |
title_sort | functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245056/ https://www.ncbi.nlm.nih.gov/pubmed/37292094 http://dx.doi.org/10.3389/fbioe.2023.1160577 |
work_keys_str_mv | AT fadilahnurizzahmd functionalisedbiomatrixforwoundhealingandcutaneousregenerationfutureimpactfulmedicalproductsinclinicaltranslationandprecisionmedicine AT rihashaimamaliha functionalisedbiomatrixforwoundhealingandcutaneousregenerationfutureimpactfulmedicalproductsinclinicaltranslationandprecisionmedicine AT mazlanzawani functionalisedbiomatrixforwoundhealingandcutaneousregenerationfutureimpactfulmedicalproductsinclinicaltranslationandprecisionmedicine AT wenadzimpohyuen functionalisedbiomatrixforwoundhealingandcutaneousregenerationfutureimpactfulmedicalproductsinclinicaltranslationandprecisionmedicine AT haolooiqi functionalisedbiomatrixforwoundhealingandcutaneousregenerationfutureimpactfulmedicalproductsinclinicaltranslationandprecisionmedicine AT josephblessy functionalisedbiomatrixforwoundhealingandcutaneousregenerationfutureimpactfulmedicalproductsinclinicaltranslationandprecisionmedicine AT maarofmanira functionalisedbiomatrixforwoundhealingandcutaneousregenerationfutureimpactfulmedicalproductsinclinicaltranslationandprecisionmedicine AT thomassabu functionalisedbiomatrixforwoundhealingandcutaneousregenerationfutureimpactfulmedicalproductsinclinicaltranslationandprecisionmedicine AT mottaantonella functionalisedbiomatrixforwoundhealingandcutaneousregenerationfutureimpactfulmedicalproductsinclinicaltranslationandprecisionmedicine AT fauzimhbusra functionalisedbiomatrixforwoundhealingandcutaneousregenerationfutureimpactfulmedicalproductsinclinicaltranslationandprecisionmedicine |