Identification of a druggable pocket of the calcium-activated chloride channel TMEM16A in its open state

The calcium-activated chloride channel TMEM16A is a potential drug target to treat hypertension, secretory diarrhea, and several cancers. However, all reported TMEM16A structures are either closed or desensitized, and direct inhibition of the open state by drug molecules lacks a reliable structural...

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Detalles Bibliográficos
Autores principales: Shi, Sai, Ma, Biao, Ji, Qiushuang, Guo, Shuai, An, Hailong, Ye, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245117/
https://www.ncbi.nlm.nih.gov/pubmed/37142220
http://dx.doi.org/10.1016/j.jbc.2023.104780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245117/
https://www.ncbi.nlm.nih.gov/pubmed/37142220
http://dx.doi.org/10.1016/j.jbc.2023.104780

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