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Safety and efficacy of the feed additive 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 for all animal species (FEFANA asbl)
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 (thiazoles, thiophene and thiazoline), when used as sensory additive (flavourings) in feed for all animal sp...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245293/ https://www.ncbi.nlm.nih.gov/pubmed/37293568 http://dx.doi.org/10.2903/j.efsa.2023.8051 |
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author | Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Brantom, Paul Chesson, Andrew Westendorf, Johannes Manini, Paola Dusemund, Birgit |
author_facet | Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Brantom, Paul Chesson, Andrew Westendorf, Johannes Manini, Paola Dusemund, Birgit |
collection | PubMed |
description | Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 (thiazoles, thiophene and thiazoline), when used as sensory additive (flavourings) in feed for all animal species. The FEEDAP Panel concluded that 4‐methyl‐5‐vinylthiazole [15.018] was safe at the maximum proposed use level of 0.5 mg/kg complete feed for veal calves (milk replacer), dogs, salmonids and ornamental fish. For the other species, the calculated safe concentrations in complete feed are: 0.4 mg/kg for cattle for fattening, sheep/goat, horses and cats; 0.3 mg/kg for sows and dairy cows; 0.2 mg/kg for piglets, pigs for fattening, rabbits and laying hens; and 0.1 mg/kg for chickens for fattening and turkeys for fattening. These conclusions were extrapolated to other physiologically related species. For any other species, the additive was considered safe at 0.1 mg/kg complete feed. No safety concern would arise for the consumer from the use the additive up to the maximum proposed use level in feed. The additive should be considered as irritant to skin and eyes and the respiratory tract, and as dermal and respiratory sensitisers. The use of 4‐methyl‐5‐vinylthiazole [15.018] as a flavour in animal feed was not expected to pose a risk to the environment. Since the compound under assessment is used in food as flavouring and its function in feed is essentially the same as that in food, no further demonstration of efficacy was considered necessary. |
format | Online Article Text |
id | pubmed-10245293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102452932023-06-08 Safety and efficacy of the feed additive 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 for all animal species (FEFANA asbl) Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Brantom, Paul Chesson, Andrew Westendorf, Johannes Manini, Paola Dusemund, Birgit EFSA J Scientific Opinion Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 (thiazoles, thiophene and thiazoline), when used as sensory additive (flavourings) in feed for all animal species. The FEEDAP Panel concluded that 4‐methyl‐5‐vinylthiazole [15.018] was safe at the maximum proposed use level of 0.5 mg/kg complete feed for veal calves (milk replacer), dogs, salmonids and ornamental fish. For the other species, the calculated safe concentrations in complete feed are: 0.4 mg/kg for cattle for fattening, sheep/goat, horses and cats; 0.3 mg/kg for sows and dairy cows; 0.2 mg/kg for piglets, pigs for fattening, rabbits and laying hens; and 0.1 mg/kg for chickens for fattening and turkeys for fattening. These conclusions were extrapolated to other physiologically related species. For any other species, the additive was considered safe at 0.1 mg/kg complete feed. No safety concern would arise for the consumer from the use the additive up to the maximum proposed use level in feed. The additive should be considered as irritant to skin and eyes and the respiratory tract, and as dermal and respiratory sensitisers. The use of 4‐methyl‐5‐vinylthiazole [15.018] as a flavour in animal feed was not expected to pose a risk to the environment. Since the compound under assessment is used in food as flavouring and its function in feed is essentially the same as that in food, no further demonstration of efficacy was considered necessary. John Wiley and Sons Inc. 2023-06-07 /pmc/articles/PMC10245293/ /pubmed/37293568 http://dx.doi.org/10.2903/j.efsa.2023.8051 Text en © 2023 European Food Safety Authority. EFSA Journal published by Wiley‐VCH GmbH on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Brantom, Paul Chesson, Andrew Westendorf, Johannes Manini, Paola Dusemund, Birgit Safety and efficacy of the feed additive 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 for all animal species (FEFANA asbl) |
title | Safety and efficacy of the feed additive 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 for all animal species (FEFANA asbl) |
title_full | Safety and efficacy of the feed additive 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 for all animal species (FEFANA asbl) |
title_fullStr | Safety and efficacy of the feed additive 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 for all animal species (FEFANA asbl) |
title_full_unstemmed | Safety and efficacy of the feed additive 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 for all animal species (FEFANA asbl) |
title_short | Safety and efficacy of the feed additive 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 for all animal species (FEFANA asbl) |
title_sort | safety and efficacy of the feed additive 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 for all animal species (fefana asbl) |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245293/ https://www.ncbi.nlm.nih.gov/pubmed/37293568 http://dx.doi.org/10.2903/j.efsa.2023.8051 |
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