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Peroxisome Proliferator-Activated Receptor α and γ Gene Polymorphisms among South Indian Patients with Diabetic Dyslipidaemia
BACKGROUND: Peroxisome proliferator-activated receptors (PPAR) α and γ genes play an important role in dyslipidaemia of T2DM. AIMS: To estimate the frequency distribution of PPAR α and γ gene polymorphisms in South Indian T2DM patients with dyslipidaemia compared to healthy controls. Normative frequ...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245317/ https://www.ncbi.nlm.nih.gov/pubmed/37292073 http://dx.doi.org/10.4103/ijem.ijem_451_22 |
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author | Bage, Isaac J. Kamalanathan, Sadishkumar Selvarajan, Sandhiya Sahoo, Jayaprakash Mathaiyan, Jayanthi Naik, Dukhabandhu |
author_facet | Bage, Isaac J. Kamalanathan, Sadishkumar Selvarajan, Sandhiya Sahoo, Jayaprakash Mathaiyan, Jayanthi Naik, Dukhabandhu |
author_sort | Bage, Isaac J. |
collection | PubMed |
description | BACKGROUND: Peroxisome proliferator-activated receptors (PPAR) α and γ genes play an important role in dyslipidaemia of T2DM. AIMS: To estimate the frequency distribution of PPAR α and γ gene polymorphisms in South Indian T2DM patients with dyslipidaemia compared to healthy controls. Normative frequencies of SNPs were established and compared with data for 1000 genome populations. METHODS: Eligible 382 cases and 336 age and sex-matched controls were enrolled. Six SNPs in PPARα [rs1800206 C>G (Leu162Val), rs4253778 G>C, rs135542 T>C] and PPARγ [rs3856806 (C>T), rs10865710 (C>G), rs1805192 C>G (Pro12Ala)] genes were selected for genotyping. RESULTS: The allele and gene frequencies did not significantly differ between the diabetic dyslipidaemia cases and healthy controls. However, they were significantly different from that of 1000 genome populations except for rs1800206 C>G (Leu162Val) and rs1805192 C>G (Pro12Ala). CONCLUSION: The studied polymorphisms in PPARα and PPARγ genes are not associated with diabetic dyslipidaemia among South Indian patients. |
format | Online Article Text |
id | pubmed-10245317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-102453172023-06-08 Peroxisome Proliferator-Activated Receptor α and γ Gene Polymorphisms among South Indian Patients with Diabetic Dyslipidaemia Bage, Isaac J. Kamalanathan, Sadishkumar Selvarajan, Sandhiya Sahoo, Jayaprakash Mathaiyan, Jayanthi Naik, Dukhabandhu Indian J Endocrinol Metab Original Article BACKGROUND: Peroxisome proliferator-activated receptors (PPAR) α and γ genes play an important role in dyslipidaemia of T2DM. AIMS: To estimate the frequency distribution of PPAR α and γ gene polymorphisms in South Indian T2DM patients with dyslipidaemia compared to healthy controls. Normative frequencies of SNPs were established and compared with data for 1000 genome populations. METHODS: Eligible 382 cases and 336 age and sex-matched controls were enrolled. Six SNPs in PPARα [rs1800206 C>G (Leu162Val), rs4253778 G>C, rs135542 T>C] and PPARγ [rs3856806 (C>T), rs10865710 (C>G), rs1805192 C>G (Pro12Ala)] genes were selected for genotyping. RESULTS: The allele and gene frequencies did not significantly differ between the diabetic dyslipidaemia cases and healthy controls. However, they were significantly different from that of 1000 genome populations except for rs1800206 C>G (Leu162Val) and rs1805192 C>G (Pro12Ala). CONCLUSION: The studied polymorphisms in PPARα and PPARγ genes are not associated with diabetic dyslipidaemia among South Indian patients. Wolters Kluwer - Medknow 2023 2023-04-14 /pmc/articles/PMC10245317/ /pubmed/37292073 http://dx.doi.org/10.4103/ijem.ijem_451_22 Text en Copyright: © 2023 Indian Journal of Endocrinology and Metabolism https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Bage, Isaac J. Kamalanathan, Sadishkumar Selvarajan, Sandhiya Sahoo, Jayaprakash Mathaiyan, Jayanthi Naik, Dukhabandhu Peroxisome Proliferator-Activated Receptor α and γ Gene Polymorphisms among South Indian Patients with Diabetic Dyslipidaemia |
title | Peroxisome Proliferator-Activated Receptor α and γ Gene Polymorphisms among South Indian Patients with Diabetic Dyslipidaemia |
title_full | Peroxisome Proliferator-Activated Receptor α and γ Gene Polymorphisms among South Indian Patients with Diabetic Dyslipidaemia |
title_fullStr | Peroxisome Proliferator-Activated Receptor α and γ Gene Polymorphisms among South Indian Patients with Diabetic Dyslipidaemia |
title_full_unstemmed | Peroxisome Proliferator-Activated Receptor α and γ Gene Polymorphisms among South Indian Patients with Diabetic Dyslipidaemia |
title_short | Peroxisome Proliferator-Activated Receptor α and γ Gene Polymorphisms among South Indian Patients with Diabetic Dyslipidaemia |
title_sort | peroxisome proliferator-activated receptor α and γ gene polymorphisms among south indian patients with diabetic dyslipidaemia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245317/ https://www.ncbi.nlm.nih.gov/pubmed/37292073 http://dx.doi.org/10.4103/ijem.ijem_451_22 |
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