Cargando…

Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children

BACKGROUND: Malaria is a deadly disease caused by Plasmodium spp. Several blood phenotypes have been associated with malarial resistance, which suggests a genetic component to immune protection. METHODS: One hundred and eighty-seven single nucleotide polymorphisms (SNPs) in 37 candidate genes were g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ariff, Amir, Song, Yong, Aguilar, Ruth, Nhabomba, Augusto, Manaca, Maria Nelia, Khoo, Siew-Kim, Wiertsema, Selma, Bassat, Quique, Barbosa, Arnoldo, Quintó, Llorenç, Laing, Ingrid A., Guinovart, Caterina, Alonso, Pedro L., Dobaño, Carlota, Le Souëf, Peter, Zhang, Guicheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245343/ https://www.ncbi.nlm.nih.gov/pubmed/37287037 http://dx.doi.org/10.1186/s12936-023-04549-8

Ejemplares similares

Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life
por: Song, Yong, et al.
Publicado: (2018)

Plasma advanced oxidative protein products are associated with anti-oxidative stress pathway genes and malaria in a longitudinal cohort
por: Zhang, Guicheng, et al.
Publicado: (2014)

Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique
por: Nhabomba, Augusto J, et al.
Publicado: (2014)

The Role of Age and Exposure to Plasmodium falciparum in the Rate of Acquisition of Naturally Acquired Immunity: A Randomized Controlled Trial
por: Guinovart, Caterina, et al.
Publicado: (2012)

Comparison of commercial kits to measure cytokine responses to Plasmodium falciparum by multiplex microsphere suspension array technology
por: Berthoud, Tamara K, et al.
Publicado: (2011)

A direct comparison of real time PCR on plasma and blood to detect Plasmodium falciparum infection in children
por: Lamikanra, Abigail A, et al.
Publicado: (2012)

IgM and IgG against Plasmodium falciparum lysate as surrogates of malaria exposure and protection during pregnancy
por: Mayor, Alfredo, et al.
Publicado: (2018)

High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection
por: Dobaño, Carlota, et al.
Publicado: (2018)

Making sense of emerging evidence on the non-specific effects of the BCG vaccine on malaria risk and neonatal mortality
por: Bassat, Quique, et al.
Publicado: (2020)

Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case–control study
por: Rovira-Vallbona, Eduard, et al.
Publicado: (2012)

Maternal Genetic Variants of IL4/IL13 Pathway Genes on IgE With "Western or Eastern Environments/Lifestyles"
por: Zhang, Guicheng, et al.
Publicado: (2014)

Performance of Multiplex Commercial Kits to Quantify Cytokine and Chemokine Responses in Culture Supernatants from Plasmodium falciparum Stimulations
por: Moncunill, Gemma, et al.
Publicado: (2013)

Cytokine and Antibody Responses to Plasmodium falciparum in Naïve Individuals during a First Malaria Episode: Effect of Age and Malaria Exposure
por: Moncunill, Gemma, et al.
Publicado: (2013)

Insights into Long-Lasting Protection Induced by RTS,S/AS02A Malaria Vaccine: Further Results from a Phase IIb Trial in Mozambican Children
por: Guinovart, Caterina, et al.
Publicado: (2009)

Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes
por: Song, Yong, et al.
Publicado: (2017)

Long-lasting insecticidal nets no longer effectively kill the highly resistant Anopheles funestus of southern Mozambique
por: Glunt, Katey D, et al.
Publicado: (2015)

Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort
por: Owens, Louisa, et al.
Publicado: (2018)

Lower Respiratory Tract Infections Associated with Rhinovirus during Infancy and Increased Risk of Wheezing during Childhood. A Cohort Study
por: O’Callaghan-Gordo, Cristina, et al.
Publicado: (2013)

High Antibody Responses against Plasmodium falciparum in Immigrants after Extended Periods of Interrupted Exposure to Malaria
por: Moncunill, Gemma, et al.
Publicado: (2013)

Immunoglobulins against the surface of Plasmodium falciparum-infected erythrocytes increase one month after delivery
por: Mayor, Alfredo, et al.
Publicado: (2012)

Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone
por: Mandomando, Inácio, et al.
Publicado: (2020)

Procalcitonin and C-Reactive Protein for Invasive Bacterial Pneumonia Diagnosis among Children in Mozambique, a Malaria-Endemic Area
por: Díez-Padrisa, Núria, et al.
Publicado: (2010)

Epidemiology, Molecular Characterization and Antibiotic Resistance of Neisseria meningitidis from Patients ≤15 Years in Manhiça, Rural Mozambique
por: Ibarz-Pavón, Ana Belén, et al.
Publicado: (2011)

Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV
por: Annamalay, Alicia A., et al.
Publicado: (2016)

The role of HIV infection in the etiology and epidemiology of diarrheal disease among children aged 0–59 months in Manhiça District, Rural Mozambique
por: Acácio, Sozinho, et al.
Publicado: (2018)

Risk factors for death among children 0–59 months of age with moderate-to-severe diarrhea in Manhiça district, southern Mozambique
por: Acácio, Sozinho, et al.
Publicado: (2019)

Assessment of exposure to DDT and metabolites after indoor residual spraying through the analysis of thatch material from rural African dwellings
por: Manaca, Maria N., et al.
Publicado: (2011)

Infant mortality and morbidity associated with preterm and small-for-gestational-age births in Southern Mozambique: A retrospective cohort study
por: García-Basteiro, Alberto L., et al.
Publicado: (2017)

Personal Network Inference Unveils Heterogeneous Immune Response Patterns to Viral Infection in Children with Acute Wheezing
por: Coleman, Laura A., et al.
Publicado: (2021)

Molecular Detection of Soil-Transmitted Helminths and Enteric Protozoa Infection in Children and Its Association with Household Water and Sanitation in Manhiça District, Southern Mozambique
por: Grau-Pujol, Berta, et al.
Publicado: (2021)

The Use of Artemether-Lumefantrine for the Treatment of Uncomplicated Plasmodium vivax Malaria
por: Bassat, Quique
Publicado: (2011)

Safety, Immunogenicity and Duration of Protection of the RTS,S/AS02(D) Malaria Vaccine: One Year Follow-Up of a Randomized Controlled Phase I/IIb Trial
por: Aide, Pedro, et al.
Publicado: (2010)

A prospective cohort study to assess the micro-epidemiology of Plasmodium falciparum clinical malaria in Ilha Josina Machel (Manhiça, Mozambique)
por: Galatas, Beatriz, et al.
Publicado: (2016)

An Autopsy Study of Maternal Mortality in Mozambique: The Contribution of Infectious Diseases
por: Menéndez, Clara, et al.
Publicado: (2008)

Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican Children
por: Quelhas, Diana, et al.
Publicado: (2012)

Multiplexing detection of IgG against Plasmodium falciparum pregnancy-specific antigens
por: Fonseca, Ana Maria, et al.
Publicado: (2017)

Epidemiology and clinical presentation of community-acquired Staphylococcus aureus bacteraemia in children under 5 years of age admitted to the Manhiça District Hospital, Mozambique, 2001–2019
por: Garrine, Marcelino, et al.
Publicado: (2023)

Health Care Utilization and Attitudes Survey in Cases of Moderate-to-Severe Diarrhea among Children Ages 0–59 Months in the District of Manhiça, Southern Mozambique
por: Nhampossa, Tacilta, et al.
Publicado: (2013)

Aberrant Expression of TLR2, TLR7, TLR9, Splicing Variants of TLR4 and MYD88 in Chronic Lymphocytic Leukemia Patients
por: Skorka, Katarzyna, et al.
Publicado: (2021)

Burden of invasive pneumococcal disease among children in rural Mozambique: 2001-2012
por: Sigaúque, Betuel, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ufbnrm8s2gk87niu4ujkn4nvfb