Targeting CXCR4 abrogates resistance to trastuzumab by blocking cell cycle progression and synergizes with docetaxel in breast cancer treatment

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BACKGROUND: Although trastuzumab and other HER2-targeted therapies have significantly improved survival in patients with HER2 overexpressed or amplified (HER2+) breast cancer, a significant proportion of patients do not respond or eventually develop clinical resistance. Strategies to reverse trastuz...

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Detalles Bibliográficos
Autores principales: Liu, Shuying, Xie, Shelly M., Liu, Wenbin, Gagea, Mihai, Hanker, Ariella B., Nguyen, Nguyen, Singareeka Raghavendra, Akshara, Yang-Kolodji, Gloria, Chu, Fuliang, Neelapu, Sattva S., Marchese, Adriano, Hanash, Samir, Zimmermann, Johann, Arteaga, Carlos L., Tripathy, Debasish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245436/
https://www.ncbi.nlm.nih.gov/pubmed/37280713
http://dx.doi.org/10.1186/s13058-023-01665-w

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