Atrial epicardial adipose tissue abundantly secretes myeloperoxidase and activates atrial fibroblasts in patients with atrial fibrillation

BACKGROUND: Epicardial adipose tissue (EAT) secretome induces fibrosis. Fibrosis, primarily extracellular matrix (ECM) produced by fibroblasts, creates a substrate for atrial fibrillation (AF). Whether the EAT secretome from patients with AF activates human atrial fibroblasts and through which compo...

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Detalles Bibliográficos
Autores principales: Meulendijks, Eva R., Al-Shama, Rushd F. M., Kawasaki, Makiri, Fabrizi, Benedetta, Neefs, Jolien, Wesselink, Robin, Ernault, Auriane C., Piersma, Sander, Pham, Thang V., Jimenez, Connie R., Knol, Jaco C., van Boven, Wim J. P., Driessen, Antoine H. G., de Vries, Tim A. C., van der Leeden, Britt, Niessen, Hans W. M., de Boer, Onno J., Krul, Sébastien P. J., de Groot, Joris R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245533/
https://www.ncbi.nlm.nih.gov/pubmed/37280612
http://dx.doi.org/10.1186/s12967-023-04231-2

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