A new antibiotic from an uncultured bacterium binds to an immutable target

Antimicrobial resistance is a leading mortality factor worldwide. Here we report the discovery of clovibactin, a new antibiotic, isolated from uncultured soil bacteria. Clovibactin efficiently kills drug-resistant bacterial pathogens without detectable resistance. Using biochemical assays, solid-sta...

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Detalles Bibliográficos
Autores principales: Shukla, Rhythm, Peoples, Aaron J., Ludwig, Kevin C., Maity, Sourav, Derks, Maik G.N., de Benedetti, Stefania, Krueger, Annika M, Vermeulen, Bram J.A., Lavore, Francesca, Honorato, Rodrigo V., Grein, Fabian, Bonvin, Alexandre, Kubitscheck, Ulrich, Breukink, Eefjan, Achorn, Catherine, Nitti, Anthony, Schwalen, Christopher J., Spoering, Amy L., Ling, Losee Lucy, Hughes, Dallas, Lelli, Moreno, Roos, Wouter H., Lewis, Kim, Schneider, Tanja, Weingarth, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245560/
https://www.ncbi.nlm.nih.gov/pubmed/37292624
http://dx.doi.org/10.1101/2023.05.15.540765

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