Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2A

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3-cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines, including the chemical probe SGC-CK2–1, are potent and selective inhibitors of CSNK2A in cells but have limited utility in animal models due to their poor pharmacokinetic properties. While developing analogs with reduced intrinsic clearance and...

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Detalles Bibliográficos
Autores principales: Yang, Xuan, Ong, Han Wee, Dickmander, Rebekah J., Smith, Jeffery L., Brown, Jason W., Tao, William, Chang, Edcon, Moorman, Nathaniel J., Axtman, Alison D., Willson, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245575/
https://www.ncbi.nlm.nih.gov/pubmed/37292607
http://dx.doi.org/10.1101/2023.05.15.540828
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