Comparative analysis of drug-like EP300/CREBBP acetyltransferase inhibitors

The human acetyltransferase paralogs EP300 and CREBBP are master regulators of lysine acetylation whose activity has been implicated in various cancers. In the half-decade since the first drug-like inhibitors of these proteins were reported, three unique molecular scaffolds have taken precedent: an...

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Detalles Bibliográficos
Autores principales: Crawford, McKenna C., Tripu, Deepika R., Barritt, Samuel A., Jing, Yihang, Gallimore, Diamond, Kales, Stephen C., Bhanu, Natarajan V., Xiong, Ying, Fang, Yuhong, Butler, Kamaria A. T., LeClair, Christopher A., Coussens, Nathan P., Simeonov, Anton, Garcia, Benjamin A., Dibble, Christian C., Meier, Jordan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245587/
https://www.ncbi.nlm.nih.gov/pubmed/37292747
http://dx.doi.org/10.1101/2023.05.15.540887

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