Cargando…
Significance of ypTNM stage in determining the prognosis and therapy after surgery for locally advanced rectal cancer
BACKGROUND: In the current NCCN guidelines, the prognosis and adjuvant chemotherapy of patients who underwent neoadjuvant chemoradiotherapy (nCRT) are based on pre-radiotherapy clinical TNM (cTNM) stage. However, the value of neoadjuvant pathologic TNM (ypTNM) stage is not clearly described. METHODS...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245591/ https://www.ncbi.nlm.nih.gov/pubmed/37287039 http://dx.doi.org/10.1186/s12957-023-03059-w |
_version_ | 1785054892372525056 |
---|---|
author | Chen, Yue Sun, Jiayu Dong, Xinxin Sun, Deyu Qu, Yanli |
author_facet | Chen, Yue Sun, Jiayu Dong, Xinxin Sun, Deyu Qu, Yanli |
author_sort | Chen, Yue |
collection | PubMed |
description | BACKGROUND: In the current NCCN guidelines, the prognosis and adjuvant chemotherapy of patients who underwent neoadjuvant chemoradiotherapy (nCRT) are based on pre-radiotherapy clinical TNM (cTNM) stage. However, the value of neoadjuvant pathologic TNM (ypTNM) stage is not clearly described. METHODS: This retrospective study investigated the prognosis and adjuvant chemotherapy which based on ypTNM stage compared to cTNM stage. Between 2010 and 2015, a total of 316 rectal cancer patients who underwent nCRT, followed by total mesorectal excision (TME), were included for analysis. RESULTS: Our findings revealed that cTNM stage was the only significant independent factor in the pCR group (HR = 6.917, 95% CI: 1.133–42.216, P = 0.038). In the non-pCR group, ypTNM stage was more important than cTNM stage in prognosis (HR = 2.704, 95% CI: 1.811–4.038, P < 0.001). In ypTNM III stage group, there was a statistically significant difference in prognosis between the patients with and without adjuvant chemotherapy (HR = 1.943, 95% CI: 1.015–3.722, P = 0.040), but there was no significant difference in cTNM III stage group (HR = 1.430, 95% CI: 0.728–2.806, P = 0.294). CONCLUSIONS: We concluded that ypTNM stage, rather than cTNM stage, might be a more important factor in the prognosis and adjuvant chemotherapy of patients with rectal cancer who underwent nCRT. |
format | Online Article Text |
id | pubmed-10245591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102455912023-06-08 Significance of ypTNM stage in determining the prognosis and therapy after surgery for locally advanced rectal cancer Chen, Yue Sun, Jiayu Dong, Xinxin Sun, Deyu Qu, Yanli World J Surg Oncol Research BACKGROUND: In the current NCCN guidelines, the prognosis and adjuvant chemotherapy of patients who underwent neoadjuvant chemoradiotherapy (nCRT) are based on pre-radiotherapy clinical TNM (cTNM) stage. However, the value of neoadjuvant pathologic TNM (ypTNM) stage is not clearly described. METHODS: This retrospective study investigated the prognosis and adjuvant chemotherapy which based on ypTNM stage compared to cTNM stage. Between 2010 and 2015, a total of 316 rectal cancer patients who underwent nCRT, followed by total mesorectal excision (TME), were included for analysis. RESULTS: Our findings revealed that cTNM stage was the only significant independent factor in the pCR group (HR = 6.917, 95% CI: 1.133–42.216, P = 0.038). In the non-pCR group, ypTNM stage was more important than cTNM stage in prognosis (HR = 2.704, 95% CI: 1.811–4.038, P < 0.001). In ypTNM III stage group, there was a statistically significant difference in prognosis between the patients with and without adjuvant chemotherapy (HR = 1.943, 95% CI: 1.015–3.722, P = 0.040), but there was no significant difference in cTNM III stage group (HR = 1.430, 95% CI: 0.728–2.806, P = 0.294). CONCLUSIONS: We concluded that ypTNM stage, rather than cTNM stage, might be a more important factor in the prognosis and adjuvant chemotherapy of patients with rectal cancer who underwent nCRT. BioMed Central 2023-06-07 /pmc/articles/PMC10245591/ /pubmed/37287039 http://dx.doi.org/10.1186/s12957-023-03059-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Chen, Yue Sun, Jiayu Dong, Xinxin Sun, Deyu Qu, Yanli Significance of ypTNM stage in determining the prognosis and therapy after surgery for locally advanced rectal cancer |
title | Significance of ypTNM stage in determining the prognosis and therapy after surgery for locally advanced rectal cancer |
title_full | Significance of ypTNM stage in determining the prognosis and therapy after surgery for locally advanced rectal cancer |
title_fullStr | Significance of ypTNM stage in determining the prognosis and therapy after surgery for locally advanced rectal cancer |
title_full_unstemmed | Significance of ypTNM stage in determining the prognosis and therapy after surgery for locally advanced rectal cancer |
title_short | Significance of ypTNM stage in determining the prognosis and therapy after surgery for locally advanced rectal cancer |
title_sort | significance of yptnm stage in determining the prognosis and therapy after surgery for locally advanced rectal cancer |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245591/ https://www.ncbi.nlm.nih.gov/pubmed/37287039 http://dx.doi.org/10.1186/s12957-023-03059-w |
work_keys_str_mv | AT chenyue significanceofyptnmstageindeterminingtheprognosisandtherapyaftersurgeryforlocallyadvancedrectalcancer AT sunjiayu significanceofyptnmstageindeterminingtheprognosisandtherapyaftersurgeryforlocallyadvancedrectalcancer AT dongxinxin significanceofyptnmstageindeterminingtheprognosisandtherapyaftersurgeryforlocallyadvancedrectalcancer AT sundeyu significanceofyptnmstageindeterminingtheprognosisandtherapyaftersurgeryforlocallyadvancedrectalcancer AT quyanli significanceofyptnmstageindeterminingtheprognosisandtherapyaftersurgeryforlocallyadvancedrectalcancer |