Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential

N(6)-methyladenosine (m(6)A) is the most prevalent and well-characterized internal chemical modification in eukaryotic RNA, influencing gene expression and phenotypic changes by controlling RNA fate. Insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) preferentially function as m(6)A effect...

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Autores principales: Zhu, Tian-Yu, Hong, Lian-Lian, Ling, Zhi-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245617/
https://www.ncbi.nlm.nih.gov/pubmed/37280679
http://dx.doi.org/10.1186/s40364-023-00499-0
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author Zhu, Tian-Yu
Hong, Lian-Lian
Ling, Zhi-Qiang
author_facet Zhu, Tian-Yu
Hong, Lian-Lian
Ling, Zhi-Qiang
author_sort Zhu, Tian-Yu
collection PubMed
description N(6)-methyladenosine (m(6)A) is the most prevalent and well-characterized internal chemical modification in eukaryotic RNA, influencing gene expression and phenotypic changes by controlling RNA fate. Insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) preferentially function as m(6)A effector proteins, promoting stability and translation of m(6)A-modified RNAs. IGF2BPs, particularly IGF2BP1 and IGF2BP3, are widely recognized as oncofetal proteins predominantly expressed in cancer rather than normal tissues, playing a critical role in tumor initiation and progression. Consequently, IGF2BPs hold potential for clinical applications and serve as a good choice for targeted treatment strategies. In this review, we discuss the functions and mechanisms of IGF2BPs as m(6)A readers and explore the therapeutic potential of targeting IGF2BPs in human cancer.
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spelling pubmed-102456172023-06-08 Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential Zhu, Tian-Yu Hong, Lian-Lian Ling, Zhi-Qiang Biomark Res Review N(6)-methyladenosine (m(6)A) is the most prevalent and well-characterized internal chemical modification in eukaryotic RNA, influencing gene expression and phenotypic changes by controlling RNA fate. Insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) preferentially function as m(6)A effector proteins, promoting stability and translation of m(6)A-modified RNAs. IGF2BPs, particularly IGF2BP1 and IGF2BP3, are widely recognized as oncofetal proteins predominantly expressed in cancer rather than normal tissues, playing a critical role in tumor initiation and progression. Consequently, IGF2BPs hold potential for clinical applications and serve as a good choice for targeted treatment strategies. In this review, we discuss the functions and mechanisms of IGF2BPs as m(6)A readers and explore the therapeutic potential of targeting IGF2BPs in human cancer. BioMed Central 2023-06-06 /pmc/articles/PMC10245617/ /pubmed/37280679 http://dx.doi.org/10.1186/s40364-023-00499-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhu, Tian-Yu
Hong, Lian-Lian
Ling, Zhi-Qiang
Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential
title Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential
title_full Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential
title_fullStr Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential
title_full_unstemmed Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential
title_short Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential
title_sort oncofetal protein igf2bps in human cancer: functions, mechanisms and therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245617/
https://www.ncbi.nlm.nih.gov/pubmed/37280679
http://dx.doi.org/10.1186/s40364-023-00499-0
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AT honglianlian oncofetalproteinigf2bpsinhumancancerfunctionsmechanismsandtherapeuticpotential
AT lingzhiqiang oncofetalproteinigf2bpsinhumancancerfunctionsmechanismsandtherapeuticpotential

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