Predicting gene level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework

The JAK-STAT pathway integrates complex cytokine signals via a limited number of molecular components, inspiring numerous efforts to clarify the diversity and specificity of STAT transcription factor function. We developed a computational workflow to make global cytokine-induced gene predictions fro...

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Detalles Bibliográficos
Autores principales: Cheemalavagu, Neha, Shoger, Karsen E., Cao, Yuqi M., Michalides, Brandon A., Botta, Samuel A., Faeder, James R., Gottschalk, Rachel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245690/
https://www.ncbi.nlm.nih.gov/pubmed/37292918
http://dx.doi.org/10.1101/2023.05.19.541151

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