Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose limitation

Human cytomegalovirus (HCMV) modulates cellular metabolism to support productive infection, and the HCMV U(L)38 protein drives many aspects of this HCMV-induced metabolic program. However, it remains to be determined whether virally-induced metabolic alterations might induce novel therapeutic vulner...

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Detalles Bibliográficos
Autores principales: Raymonda, Matthew H., Rodríguez-Sánchez, Irene, Schafer, Xenia L., Smorodintsev-Schiller, Leonid, Harris, Isaac S., Munger, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245705/
https://www.ncbi.nlm.nih.gov/pubmed/37292722
http://dx.doi.org/10.1101/2023.05.17.541212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245705/
https://www.ncbi.nlm.nih.gov/pubmed/37292722
http://dx.doi.org/10.1101/2023.05.17.541212

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