Cargando…

Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose limitation

Human cytomegalovirus (HCMV) modulates cellular metabolism to support productive infection, and the HCMV U(L)38 protein drives many aspects of this HCMV-induced metabolic program. However, it remains to be determined whether virally-induced metabolic alterations might induce novel therapeutic vulner...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raymonda, Matthew H., Rodríguez-Sánchez, Irene, Schafer, Xenia L., Smorodintsev-Schiller, Leonid, Harris, Isaac S., Munger, Joshua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245705/ https://www.ncbi.nlm.nih.gov/pubmed/37292722 http://dx.doi.org/10.1101/2023.05.17.541212

Ejemplares similares

The Human Cytomegalovirus U(L)38 protein drives mTOR-independent metabolic flux reprogramming by inhibiting TSC2
por: Rodríguez-Sánchez, Irene, et al.
Publicado: (2019)

Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro
por: Raymonda, M.H., et al.
Publicado: (2022)

Human cytomegalovirus induces neuronal enolase to support virally mediated metabolic remodeling
por: Moreno, Isreal, et al.
Publicado: (2022)

Exosome Release by Glucose Deprivation Is Important for the Viability of TSC-Null Cells
por: Bae, Ji-Hyun, et al.
Publicado: (2022)

TSC22D4 interacts with Akt1 to regulate glucose metabolism
por: Demir, Sevgican, et al.
Publicado: (2022)

Targeting Rb Mutant Cancers by Inactivating TSC2
por: Searle, Jennifer S., et al.
Publicado: (2010)

The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits
por: Hoogeveen-Westerveld, Marianne, et al.
Publicado: (2012)

Subependymal giant cell astrocytomas in Tuberous Sclerosis Complex have consistent TSC1/TSC2 biallelic inactivation, and no BRAF mutations
por: Bongaarts, Anika, et al.
Publicado: (2017)

Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish
por: Kim, Seok-Hyung, et al.
Publicado: (2013)

TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1
por: Plescher, Monika, et al.
Publicado: (2015)

Tsc Gene Locus Disruption and Differences in Renal Epithelial Extracellular Vesicles
por: Kumar, Prashant, et al.
Publicado: (2021)

A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development
por: Jones, Iwan, et al.
Publicado: (2015)

Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions
por: Murai, S, et al.
Publicado: (2017)

Manipulation of Glucose Availability to Boost Cancer Immunotherapies
por: Marchesi, Federica, et al.
Publicado: (2020)

Disrupted normal ingestion during glucose intake modulates glucose kinetics in humans
por: Tsuji, Tadataka, et al.
Publicado: (2015)

Increased glucose availability sensitizes pancreatic cancer to chemotherapy
por: Vaziri-Gohar, Ali, et al.
Publicado: (2023)

Glucose signalling positively regulates aliphatic glucosinolate biosynthesis
por: Miao, Huiying, et al.
Publicado: (2013)

Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing
por: Tyburczy, Magdalena E., et al.
Publicado: (2015)

Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC1 and TSC2
por: Kwiatkowski, David J, et al.
Publicado: (2015)

The glucose metabolite methylglyoxal inhibits expression of the glucose transporter genes by inactivating the cell surface glucose sensors Rgt2 and Snf3 in yeast
por: Roy, Adhiraj, et al.
Publicado: (2016)

Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model
por: Fujimoto, Brent A., et al.
Publicado: (2021)

Evidence for population variation in TSC1 and TSC2 gene expression
por: Jentarra, Garilyn M, et al.
Publicado: (2011)

The long-term effect of mTOR inhibition on lipid and glucose metabolism in tuberous sclerosis complex: data from the Dutch TSC registry
por: Mulder, Femke V. M., et al.
Publicado: (2022)

Photodynamic Therapy by Glucose Transporter 1-Selective Light Inactivation
por: Miura, Kazuki, et al.
Publicado: (2022)

Correction for The glucose metabolite methylglyoxal inhibits expression of the glucose transporter genes by inactivating the cell surface glucose sensors Rgt2 and Snf3 in yeast
Publicado: (2016)

Aldosterone Disrupts the Intercellular Flow of Glucose in Cardiac Muscle
por: De Mello, Walmor C.
Publicado: (2015)

Dihydroxyacetone phosphate signals glucose availability to mTORC1
por: Orozco, Jose M., et al.
Publicado: (2020)

Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization
por: Brahma, Manoja K., et al.
Publicado: (2020)

Vitamin B2 enables regulation of fasting glucose availability
por: Masschelin, Peter M, et al.
Publicado: (2023)

Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3
por: Klover, Peter J, et al.
Publicado: (2017)

Analysis of the TSC1and TSC2genes in sporadic renal cell carcinomas
por: Parry, L, et al.
Publicado: (2001)

Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
por: Liu, Jie, et al.
Publicado: (2019)

Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis
por: Harfmann, Brianna D., et al.
Publicado: (2016)

Germline mutation of TSC1 or TSC2 gene in Chinese patients with bilateral renal angiomyolipomas and mutation spectrum of Chinese TSC patients
por: Jiangyi, Wang, et al.
Publicado: (2020)

Yeast glucose pathways converge on the transcriptional regulation of trehalose biosynthesis
por: Apweiler, Eva, et al.
Publicado: (2012)

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis
por: Nakano, Haruko, et al.
Publicado: (2017)

Dexmedetomidine Protects Against Oxygen–Glucose Deprivation-Induced Injury Through Inducing Astrocytes Autophagy via TSC2/mTOR Pathway
por: Zhu, Chen, et al.
Publicado: (2019)

Chemical Biology Screening Identifies a Vulnerability to Checkpoint Kinase Inhibitors in TSC2-Deficient Renal Angiomyolipomas
por: Vaughan, Robert M., et al.
Publicado: (2022)

Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism
por: Rodríguez-Sánchez, Irene, et al.
Publicado: (2019)

Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection
por: Dunn, Diana M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rb0jnm223h65q2p1guer1rceoh