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Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly

The mitochondrial chaperonin, mtHsp60, promotes the folding of newly imported and transiently misfolded proteins in the mitochondrial matrix, assisted by its co-chaperone mtHsp10. Despite its essential role in mitochondrial proteostasis, structural insights into how this chaperonin binds to clients...

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Detalles Bibliográficos
Autores principales:	Braxton, Julian R., Shao, Hao, Tse, Eric, Gestwicki, Jason E., Southworth, Daniel R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245740/ https://www.ncbi.nlm.nih.gov/pubmed/37293102 http://dx.doi.org/10.1101/2023.05.15.540872

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