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Epigenome Editing Durability Varies Widely Across Cardiovascular Disease Target Genes

BACKGROUND: Hepatic knockdown of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene or the angiopoietin-like 3 (ANGPTL3) gene has been demonstrated to reduce blood low-density lipoprotein cholesterol (LDL-C) levels, and hepatic knockdown of the angiotensinogen (AGT) gene has been demonst...

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Detalles Bibliográficos
Autores principales:	Whittaker, Madelynn N., Testa, Lauren C., Quigley, Aidan, Jindal, Ishaan, Cortez-Alvarado, Saúl V., Qu, Ping, Yang, Yifan, Alameh, Mohamad-Gabriel, Musunuru, Kiran, Wang, Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245770/ https://www.ncbi.nlm.nih.gov/pubmed/37292627 http://dx.doi.org/10.1101/2023.05.17.541156

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