Cryo-EM and Molecular Dynamics Simulations Reveal Hidden Conformational Dynamics Controlling Ammonia Transport in Human Asparagine Synthetase

How dynamical motions in enzymes might be linked to catalytic function is of significant general interest, although almost all relevant experimental data, to date, has been obtained for enzymes with a single active site. Recent advances in X-ray crystallography and cryogenic electron microscopy offe...

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Detalles Bibliográficos
Autores principales: Coricello, Adriana, Zhu, Wen, Lupia, Antonio, Gratteri, Carmen, Vos, Matthijn, Chaptal, Vincent, Alcaro, Stefano, Takagi, Yuichiro, Richards, Nigel G. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245805/
https://www.ncbi.nlm.nih.gov/pubmed/37292727
http://dx.doi.org/10.1101/2023.05.16.541009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245805/
https://www.ncbi.nlm.nih.gov/pubmed/37292727
http://dx.doi.org/10.1101/2023.05.16.541009

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