Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis

PURPOSE: PTEN loss-of-function/PI3K pathway hyperactivation occurs in ~50% of metastatic, castrate-resistant prostate cancer patients, resulting in poor therapeutic outcomes and resistance to immune checkpoint inhibitors across multiple malignancies. Our prior studies in prostate-specific PTEN/p53-d...

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Detalles Bibliográficos
Autores principales: Chaudagar, Kiranj, Hieromnimon, Hanna M., Kelley, Anne, Labadie, Brian, Shafran, Jordan, Rameshbabu, Srikrishnan, Drovetsky, Catherine, Bynoe, Kaela, Solanki, Ani, Markiewicz, Erica, Fan, Xiaobing, Loda, Massimo, Patnaik, Akash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245812/
https://www.ncbi.nlm.nih.gov/pubmed/37292972
http://dx.doi.org/10.1101/2023.05.23.540590

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