Biochemical Pathways Represented by Gene Ontology Causal Activity Models Identify Distinct Phenotypes Resulting from Mutations in Pathways

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Gene inactivation can affect the process(es) in which that gene acts and causally downstream ones, yielding diverse mutant phenotypes. Identifying the genetic pathways resulting in a given phenotype helps us understand how individual genes interact in a functional network. Computable representations...

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Detalles Bibliográficos
Autores principales: Hill, David P, Drabkin, Harold J, Smith, Cynthia L, Van Auken, Kimberly M, D’Eustachio, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245817/
https://www.ncbi.nlm.nih.gov/pubmed/37293039
http://dx.doi.org/10.1101/2023.05.22.541760
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