Changes in Active Site Loop Conformation Relate to the Transition toward a Novel Enzymatic Activity

Enzymatic promiscuity, the ability of enzymes to catalyze multiple, distinct chemical reactions, has been well documented and is hypothesized to be a major driver for the emergence of new enzymatic functions. Yet, the molecular mechanisms involved in the transition from one activity to another remai...

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Detalles Bibliográficos
Autores principales: Jacquet, Pauline, Billot, Raphaël, Shimon, Amir, Hoekstra, Nathan, Bergonzi, Céline, Jenks, Anthony, Chabrière, Eric, Daudé, David, Elias, Mikael H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245850/
https://www.ncbi.nlm.nih.gov/pubmed/37292757
http://dx.doi.org/10.1101/2023.05.22.541809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245850/
https://www.ncbi.nlm.nih.gov/pubmed/37292757
http://dx.doi.org/10.1101/2023.05.22.541809

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