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Changes in Active Site Loop Conformation Relate to the Transition toward a Novel Enzymatic Activity
Enzymatic promiscuity, the ability of enzymes to catalyze multiple, distinct chemical reactions, has been well documented and is hypothesized to be a major driver for the emergence of new enzymatic functions. Yet, the molecular mechanisms involved in the transition from one activity to another remai...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245850/ https://www.ncbi.nlm.nih.gov/pubmed/37292757 http://dx.doi.org/10.1101/2023.05.22.541809 |