Cargando…
HIV-1 Vpr-induced DNA damage activates NF-κB independent of cell cycle arrest and CRL4A(DCAF1) engagement
Lentiviral accessory genes enhance replication through diverse mechanisms. HIV-1 accessory protein Vpr modulates the host DNA damage response (DDR) at multiple steps through the degradation of host proteins, cell cycle arrest, DNA damage, and both activation and repression of DDR signaling. Vpr also...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245860/ https://www.ncbi.nlm.nih.gov/pubmed/37292767 http://dx.doi.org/10.1101/2023.05.23.541990 |