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HIV-1 Vpr-induced DNA damage activates NF-κB independent of cell cycle arrest and CRL4A(DCAF1) engagement

Lentiviral accessory genes enhance replication through diverse mechanisms. HIV-1 accessory protein Vpr modulates the host DNA damage response (DDR) at multiple steps through the degradation of host proteins, cell cycle arrest, DNA damage, and both activation and repression of DDR signaling. Vpr also...

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Detalles Bibliográficos
Autores principales:	Sandoval, Carina, Fregoso, Oliver I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245860/ https://www.ncbi.nlm.nih.gov/pubmed/37292767 http://dx.doi.org/10.1101/2023.05.23.541990

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