GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

The orphan G protein-coupled receptor (GPCR) GPR161 is enriched in primary cilia, where it plays a central role in suppressing Hedgehog signaling(1). GPR161 mutations lead to developmental defects and cancers(2,3,4). The fundamental basis of how GPR161 is activated, including potential endogenous ac...

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Detalles Bibliográficos
Autores principales: Hoppe, Nicholas, Harrison, Simone, Hwang, Sun-Hee, Chen, Ziwei, Karelina, Masha, Deshpande, Ishan, Suomivuori, Carl-Mikael, Palicharla, Vivek R., Berry, Samuel P., Tschaikner, Philipp, Regele, Dominik, Covey, Douglas F., Stefan, Eduard, Marks, Debora S., Reiter, Jeremy, Dror, Ron O., Evers, Alex S., Mukhopadhyay, Saikat, Manglik, Aashish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245861/
https://www.ncbi.nlm.nih.gov/pubmed/37292845
http://dx.doi.org/10.1101/2023.05.23.540554

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