Characterizing glucokinase variant mechanisms using a multiplexed abundance assay

Amino acid substitutions can perturb protein activity in multiple ways. Understanding their mechanistic basis may pinpoint how residues contribute to protein function. Here, we characterize the mechanisms of human glucokinase (GCK) variants, building on our previous comprehensive study on GCK varian...

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Detalles Bibliográficos
Autores principales: Gersing, Sarah, Schulze, Thea K., Cagiada, Matteo, Stein, Amelie, Roth, Frederick P., Lindorff-Larsen, Kresten, Hartmann-Petersen, Rasmus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245906/
https://www.ncbi.nlm.nih.gov/pubmed/37292969
http://dx.doi.org/10.1101/2023.05.24.542036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245906/
https://www.ncbi.nlm.nih.gov/pubmed/37292969
http://dx.doi.org/10.1101/2023.05.24.542036

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