Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids

Nephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional units of the kidney. Here we report manipulation of p38 and YAP activity creates a synthetic niche that allows the long-term clonal expansion of primary mouse and human NPCs, and induced NPCs (iNPCs) from huma...

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Detalles Bibliográficos
Autores principales: Huang, Biao, Zeng, Zipeng, Li, Hui, Li, Zexu, Chen, Xi, Guo, Jinjin, Zhang, Chennan C., Schreiber, Megan E., Vonk, Ariel C., Xiang, Tianyuan, Patel, Tadrushi, Li, Yidan, Parvez, Riana K., Der, Balint, Chen, Jyun Hao, Liu, Zhenqing, Thornton, Matthew E., Grubbs, Brendan H., Diao, Yarui, Dou, Yali, Gnedeva, Ksenia, Lindström, Nils O., Ying, Qilong, Pastor-Soler, Nuria M., Fei, Teng, Hallows, Kenneth R., McMahon, Andrew P., Li, Zhongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10245960/
https://www.ncbi.nlm.nih.gov/pubmed/37293038
http://dx.doi.org/10.1101/2023.05.25.542343

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