Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen

The principal barrier to an HIV cure is the presence of a latent viral reservoir (LVR) made up primarily of latently infected resting CD4+ (rCD4) T-cells. Studies in the United States have shown that the LVR decays slowly (half-life=3.8 years), but this rate in African populations has been understud...

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Detalles Bibliográficos
Autores principales: Ferreira, Roux-Cil, Reynolds, Steven J., Capoferri, Adam A., Baker, Owen, Brown, Erin E., Klock, Ethan, Miller, Jernelle, Lai, Jun, Saraf, Sharada, Kirby, Charles, Lynch, Briana, Hackman, Jada, Gowanlock, Sarah N., Tomusange, Stephen, Jamiru, Samiri, Anok, Aggrey, Kityamuweesi, Taddeo, Buule, Paul, Bruno, Daniel, Martens, Craig, Rose, Rebecca, Lamers, Susanna L., Galiwango, Ronald M., Poon, Art F. Y., Quinn, Thomas C., Prodger, Jessica L., Redd, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246077/
https://www.ncbi.nlm.nih.gov/pubmed/37292785
http://dx.doi.org/10.1101/2023.05.12.23289896

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