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Composite CYP3A (CYP3A4 and CYP3A5) phenotypes and influences on tacrolimus dose adjusted concentration in adult heart transplant recipients

CYP3A5 genetic variants are associated with tacrolimus metabolism. Controversy remains on whether CYP3A4 increased [* 1B (rs2740574), *1G (rs2242480)] and decreased function [*22 (rs35599367)] genetic variants provide additional information. This study aims to address whether tacrolimus dose-adjuste...

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Detalles Bibliográficos
Autores principales:	Hernandez, Savine, Aquilante, Christina, Deininger, Kimberly, Lindenfeld, Joann, Schlendorf, Kelly, Van Driest, Sara, Liu, Michelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246090/ https://www.ncbi.nlm.nih.gov/pubmed/37292893 http://dx.doi.org/10.21203/rs.3.rs-2921796/v1

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