Improvement of synaptic plasticity and cognitive function in RASopathies—a monocentre, randomized, double-blind, parallel-group, placebo-controlled, cross-over clinical trial (SynCoRAS)

BACKGROUND: Cognitive impairment is a common medical issue in rat sarcoma (RAS) pathway disorders, so-called RASopathies, like Neurofibromatosis type 1 (NF1) or Noonan syndrome (NS). It is presumed to be caused by impaired synaptic plasticity. In animal studies, pathway-specific pharmacological inte...

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Detalles Bibliográficos
Autores principales: Jung, Nikolai H., Egert-Schwender, Silvia, Schossow, Beate, Kehl, Victoria, Wahlländer, Ute, Brich, Louisa, Janke, Viktoria, Blankenstein, Christiane, Zenker, Martin, Mall, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246096/
https://www.ncbi.nlm.nih.gov/pubmed/37280688
http://dx.doi.org/10.1186/s13063-023-07392-z

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