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PTEN regulated PI3K-p110 and AKT isoform plasticity controls metastatic prostate cancer progression

PTEN loss, one of the most frequent mutations in prostate cancer (PC), is presumed to drive disease progression through AKT activation. However, two transgenic PC models with Akt activation plus Rb loss exhibited different metastasis development: Pten/Rb(PE:−/−) mice produced systemic metastatic ade...

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Detalles Bibliográficos
Autores principales:	Miller, Karina, Degan, Seamus, Wang, Yanqing, Cohen, Joseph, Ku, Sheng-Yu, Goodrich, David, Gelman, Irwin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246239/ https://www.ncbi.nlm.nih.gov/pubmed/37292818 http://dx.doi.org/10.21203/rs.3.rs-2924750/v1

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