Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta (SNc). Rit2 is a reported PD risk allele, and recent single cell transcriptomic studies identified a major RIT2 cluster in PD D...

Descripción completa

Detalles Bibliográficos
Autores principales: Kearney, Patrick J., Zhang, Yuanxi, Tan, Yanglan, Kahuno, Elizabeth, Conklin, Tucker L., Fagan, Rita R., Pavchinskiy, Rebecca G., Shafer, Scott A., Yue, Zhenyu, Melikian, Haley E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246263/
https://www.ncbi.nlm.nih.gov/pubmed/37293098
http://dx.doi.org/10.21203/rs.3.rs-2944614/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246263/
https://www.ncbi.nlm.nih.gov/pubmed/37293098
http://dx.doi.org/10.21203/rs.3.rs-2944614/v1

Ejemplares similares