BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps

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BACKGROUND: Pro-apoptotic BAX is a central mediator of retinal ganglion cell (RGC) death after optic nerve damage. BAX activation occurs in two stages including translocation of latent BAX to the mitochondrial outer membrane (MOM) and then permeabilization of the MOM to facilitate the release of apo...

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Detalles Bibliográficos
Autores principales: Maes, Margaret E., Donahue, Ryan J., Schlamp, Cassandra L., Marola, Olivia J., Libby, Richard T., Nickells, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246290/
https://www.ncbi.nlm.nih.gov/pubmed/37292963
http://dx.doi.org/10.21203/rs.3.rs-2846437/v1
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