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Age‐specific differences in hypertension combination management and associated factors influencing treatment choice
The current hypertension guideline emphasizes combination therapy, especially single‐pill combination therapy (SPC). However, few studies compared the prevalence and factors associated with initial therapy choice across heterogeneous age groups in a current population. First, the authors consecutive...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246461/ https://www.ncbi.nlm.nih.gov/pubmed/37196052 http://dx.doi.org/10.1111/jch.14668 |
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author | Xiong, Jianfei Wang, Li Yang, Chuanxi Huang, Hengye He, Ben Shen, Lan Su, Feng |
author_facet | Xiong, Jianfei Wang, Li Yang, Chuanxi Huang, Hengye He, Ben Shen, Lan Su, Feng |
author_sort | Xiong, Jianfei |
collection | PubMed |
description | The current hypertension guideline emphasizes combination therapy, especially single‐pill combination therapy (SPC). However, few studies compared the prevalence and factors associated with initial therapy choice across heterogeneous age groups in a current population. First, the authors consecutively identified 964 treatment naïve hypertensive patients in a large academic hospital from 01/31/2019 to 01/31/2020. All patients were grouped into (1) young aged, age < 55; (2) middle‐aged, 55≤age < 65; and (3) older aged, age ≥65. The multivariable regression model examined the factors associated with the combination therapy by age group. Overall, 80 (8.3%) were young, 191 (19.8%) were middle, and 693 (71.9%) were older aged. Compared with older age, younger patients were more likely to be male, highly educated, regularly exercised, have metabolic syndrome, and less likely to have cardiovascular‐related comorbidities, with a lower systolic but higher diastolic pressure. Only one in five patients used SPC, and the prevalence decreased with age. Besides hypertension grade, young patients without catheterization or echo test were less likely to receive multiple therapies, while older patients who were male with lower weight and lower risk levels were less likely to receive multiple therapies. In conclusion, combination therapy, especially SPC, was underused in the targeted hypertensive population. Our contemporary population study showed that young patients (<55) without a history of catheterization or echo examination and male older‐aged (≥65) patients with low‐risk classification were the population most likely to be neglected. Such information can help triage medical care resources in improving SPC use. |
format | Online Article Text |
id | pubmed-10246461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102464612023-06-08 Age‐specific differences in hypertension combination management and associated factors influencing treatment choice Xiong, Jianfei Wang, Li Yang, Chuanxi Huang, Hengye He, Ben Shen, Lan Su, Feng J Clin Hypertens (Greenwich) Combination Therapy The current hypertension guideline emphasizes combination therapy, especially single‐pill combination therapy (SPC). However, few studies compared the prevalence and factors associated with initial therapy choice across heterogeneous age groups in a current population. First, the authors consecutively identified 964 treatment naïve hypertensive patients in a large academic hospital from 01/31/2019 to 01/31/2020. All patients were grouped into (1) young aged, age < 55; (2) middle‐aged, 55≤age < 65; and (3) older aged, age ≥65. The multivariable regression model examined the factors associated with the combination therapy by age group. Overall, 80 (8.3%) were young, 191 (19.8%) were middle, and 693 (71.9%) were older aged. Compared with older age, younger patients were more likely to be male, highly educated, regularly exercised, have metabolic syndrome, and less likely to have cardiovascular‐related comorbidities, with a lower systolic but higher diastolic pressure. Only one in five patients used SPC, and the prevalence decreased with age. Besides hypertension grade, young patients without catheterization or echo test were less likely to receive multiple therapies, while older patients who were male with lower weight and lower risk levels were less likely to receive multiple therapies. In conclusion, combination therapy, especially SPC, was underused in the targeted hypertensive population. Our contemporary population study showed that young patients (<55) without a history of catheterization or echo examination and male older‐aged (≥65) patients with low‐risk classification were the population most likely to be neglected. Such information can help triage medical care resources in improving SPC use. John Wiley and Sons Inc. 2023-05-17 /pmc/articles/PMC10246461/ /pubmed/37196052 http://dx.doi.org/10.1111/jch.14668 Text en © 2023 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Combination Therapy Xiong, Jianfei Wang, Li Yang, Chuanxi Huang, Hengye He, Ben Shen, Lan Su, Feng Age‐specific differences in hypertension combination management and associated factors influencing treatment choice |
title | Age‐specific differences in hypertension combination management and associated factors influencing treatment choice |
title_full | Age‐specific differences in hypertension combination management and associated factors influencing treatment choice |
title_fullStr | Age‐specific differences in hypertension combination management and associated factors influencing treatment choice |
title_full_unstemmed | Age‐specific differences in hypertension combination management and associated factors influencing treatment choice |
title_short | Age‐specific differences in hypertension combination management and associated factors influencing treatment choice |
title_sort | age‐specific differences in hypertension combination management and associated factors influencing treatment choice |
topic | Combination Therapy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246461/ https://www.ncbi.nlm.nih.gov/pubmed/37196052 http://dx.doi.org/10.1111/jch.14668 |
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