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Cardiovascular involvement in Epstein–Barr virus infection

Cardiovascular involvement is an uncommon but severe complication of Epstein–Barr virus (EBV) infection caused by direct damage and immune injury. Recently, it has drawn increasing attention due to its dismal prognosis. It can manifest in various ways, including coronary artery dilation (CAD), coron...

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Autores principales: Chen, Xinying, Li, Yingying, Deng, Lijun, Wang, Lianyu, Zhong, Wenting, Hong, Junbin, Chen, Liyu, Yang, Jinghua, Huang, Bin, Xiao, Xiaolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246501/
https://www.ncbi.nlm.nih.gov/pubmed/37292213
http://dx.doi.org/10.3389/fimmu.2023.1188330
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author Chen, Xinying
Li, Yingying
Deng, Lijun
Wang, Lianyu
Zhong, Wenting
Hong, Junbin
Chen, Liyu
Yang, Jinghua
Huang, Bin
Xiao, Xiaolan
author_facet Chen, Xinying
Li, Yingying
Deng, Lijun
Wang, Lianyu
Zhong, Wenting
Hong, Junbin
Chen, Liyu
Yang, Jinghua
Huang, Bin
Xiao, Xiaolan
author_sort Chen, Xinying
collection PubMed
description Cardiovascular involvement is an uncommon but severe complication of Epstein–Barr virus (EBV) infection caused by direct damage and immune injury. Recently, it has drawn increasing attention due to its dismal prognosis. It can manifest in various ways, including coronary artery dilation (CAD), coronary artery aneurysm (CAA), myocarditis, arrhythmias, and heart failure, among others. If not treated promptly, cardiovascular damage can progress over time and even lead to death, which poses a challenge to clinicians. Early diagnosis and treatment can improve the prognosis and reduce mortality. However, there is a lack of reliable large-scale data and evidence-based guidance for the management of cardiovascular damage. Consequently, in this review, we attempt to synthesize the present knowledge of cardiovascular damage associated with EBV and to provide an overview of the pathogenesis, classification, treatment, and prognosis, which may enhance the recognition of cardiovascular complications related to EBV and may be valuable to their clinical management.
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spelling pubmed-102465012023-06-08 Cardiovascular involvement in Epstein–Barr virus infection Chen, Xinying Li, Yingying Deng, Lijun Wang, Lianyu Zhong, Wenting Hong, Junbin Chen, Liyu Yang, Jinghua Huang, Bin Xiao, Xiaolan Front Immunol Immunology Cardiovascular involvement is an uncommon but severe complication of Epstein–Barr virus (EBV) infection caused by direct damage and immune injury. Recently, it has drawn increasing attention due to its dismal prognosis. It can manifest in various ways, including coronary artery dilation (CAD), coronary artery aneurysm (CAA), myocarditis, arrhythmias, and heart failure, among others. If not treated promptly, cardiovascular damage can progress over time and even lead to death, which poses a challenge to clinicians. Early diagnosis and treatment can improve the prognosis and reduce mortality. However, there is a lack of reliable large-scale data and evidence-based guidance for the management of cardiovascular damage. Consequently, in this review, we attempt to synthesize the present knowledge of cardiovascular damage associated with EBV and to provide an overview of the pathogenesis, classification, treatment, and prognosis, which may enhance the recognition of cardiovascular complications related to EBV and may be valuable to their clinical management. Frontiers Media S.A. 2023-05-22 /pmc/articles/PMC10246501/ /pubmed/37292213 http://dx.doi.org/10.3389/fimmu.2023.1188330 Text en Copyright © 2023 Chen, Li, Deng, Wang, Zhong, Hong, Chen, Yang, Huang and Xiao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Xinying
Li, Yingying
Deng, Lijun
Wang, Lianyu
Zhong, Wenting
Hong, Junbin
Chen, Liyu
Yang, Jinghua
Huang, Bin
Xiao, Xiaolan
Cardiovascular involvement in Epstein–Barr virus infection
title Cardiovascular involvement in Epstein–Barr virus infection
title_full Cardiovascular involvement in Epstein–Barr virus infection
title_fullStr Cardiovascular involvement in Epstein–Barr virus infection
title_full_unstemmed Cardiovascular involvement in Epstein–Barr virus infection
title_short Cardiovascular involvement in Epstein–Barr virus infection
title_sort cardiovascular involvement in epstein–barr virus infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246501/
https://www.ncbi.nlm.nih.gov/pubmed/37292213
http://dx.doi.org/10.3389/fimmu.2023.1188330
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