Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth

Controllable activation of the innate immune adapter protein – stimulator of interferon genes (STING) pathway is a critical challenge for the clinical development of STING agonists due to the potential “on-target off-tumor” toxicity caused by systematic activation of STING. Herein, we designed and s...

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Detalles Bibliográficos
Autores principales: Ding, Chunyong, Du, Mengyan, Xiong, Zhi, Wang, Xue, Li, Hongji, He, Ende, Li, Han, Dang, Yijing, Lu, Qing, Li, Shicong, Xiao, Ruoxuan, Xu, Zhiai, Jing, Lili, Deng, Liufu, Wang, Xiyuan, Geng, Meiyu, Xie, Zuoquan, Zhang, Ao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246697/
https://www.ncbi.nlm.nih.gov/pubmed/37293644
http://dx.doi.org/10.1039/d3sc01896b

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