Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor

Approximately 140 million people worldwide are homozygous carriers of APOE4 (ε4), a strong genetic risk factor for late onset familial and sporadic Alzheimer’s disease (AD), 91% of whom will develop AD at earlier age than heterozygous carriers and noncarriers. Susceptibility to AD could be reduced b...

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Detalles Bibliográficos
Autores principales: Wei, Yinghui, Zhang, Meiling, Hu, Jing, Zhou, Yingsi, Xue, Mingxing, Yin, Jianhang, Liu, Yuanhua, Feng, Hu, Zhou, Ling, Li, Zhifang, Wang, Dongshuang, Zhang, Zhiguo, Zhou, Yin, Liu, Hongbin, Yao, Ning, Zuo, Erwei, Hu, Jiazhi, Du, Yanzhi, Li, Wen, Xu, Chunlong, Yang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246723/
https://www.ncbi.nlm.nih.gov/pubmed/37285261
http://dx.doi.org/10.1093/procel/pwac043

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