Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex interactions: the potential role of astrocytes

Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-6162 (5 mg/kg), which has a high affinity for Sigma1R, significantly increased the density of accumbal shell D2R-Sigma1R and A2AR-D2R heteroreceptor complexes following cocaine self-administration. Ex vivo studies...

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Detalles Bibliográficos
Autores principales: Borroto-Escuela, Dasiel O., Lopez-Salas, Alexander, Wydra, Karolina, Bartolini, Marco, Zhou, Zilong, Frankowska, Malgorzata, Suder, Agata, Benitez-Porres, Javier, Romero-Fernandez, Wilber, Filip, Malgorzata, Fuxe, Kjell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246738/
https://www.ncbi.nlm.nih.gov/pubmed/37293542
http://dx.doi.org/10.3389/fnmol.2023.1106765

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