Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

Knowledge of aging biology needs to be expanded due to the continuously growing number of elderly people worldwide. Aging induces changes that affect all systems of the body. The risk of cardiovascular disease and cancer increases with age. In particular, the age-induced adaptation of the immune sys...

Descripción completa

Detalles Bibliográficos
Autores principales: Grifoni, Alba, Alonzi, Tonino, Alter, Galit, Noonan, Douglas McClain, Landay, Alan L., Albini, Adriana, Goletti, Delia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246744/
https://www.ncbi.nlm.nih.gov/pubmed/37292210
http://dx.doi.org/10.3389/fimmu.2023.1146704
_version_ 1785055092996571136
author Grifoni, Alba
Alonzi, Tonino
Alter, Galit
Noonan, Douglas McClain
Landay, Alan L.
Albini, Adriana
Goletti, Delia
author_facet Grifoni, Alba
Alonzi, Tonino
Alter, Galit
Noonan, Douglas McClain
Landay, Alan L.
Albini, Adriana
Goletti, Delia
author_sort Grifoni, Alba
collection PubMed
description Knowledge of aging biology needs to be expanded due to the continuously growing number of elderly people worldwide. Aging induces changes that affect all systems of the body. The risk of cardiovascular disease and cancer increases with age. In particular, the age-induced adaptation of the immune system causes a greater susceptibility to infections and contributes to the inability to control pathogen growth and immune-mediated tissue damage. Since the impact of aging on immune function, is still to be fully elucidated, this review addresses some of the recent understanding of age-related changes affecting key components of immunity. The emphasis is on immunosenescence and inflammaging that are impacted by common infectious diseases that are characterized by a high mortality, and includes COVID-19, HIV and tuberculosis.
format Online
Article
Text
id pubmed-10246744
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-102467442023-06-08 Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis Grifoni, Alba Alonzi, Tonino Alter, Galit Noonan, Douglas McClain Landay, Alan L. Albini, Adriana Goletti, Delia Front Immunol Immunology Knowledge of aging biology needs to be expanded due to the continuously growing number of elderly people worldwide. Aging induces changes that affect all systems of the body. The risk of cardiovascular disease and cancer increases with age. In particular, the age-induced adaptation of the immune system causes a greater susceptibility to infections and contributes to the inability to control pathogen growth and immune-mediated tissue damage. Since the impact of aging on immune function, is still to be fully elucidated, this review addresses some of the recent understanding of age-related changes affecting key components of immunity. The emphasis is on immunosenescence and inflammaging that are impacted by common infectious diseases that are characterized by a high mortality, and includes COVID-19, HIV and tuberculosis. Frontiers Media S.A. 2023-05-24 /pmc/articles/PMC10246744/ /pubmed/37292210 http://dx.doi.org/10.3389/fimmu.2023.1146704 Text en Copyright © 2023 Grifoni, Alonzi, Alter, Noonan, Landay, Albini and Goletti https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Grifoni, Alba
Alonzi, Tonino
Alter, Galit
Noonan, Douglas McClain
Landay, Alan L.
Albini, Adriana
Goletti, Delia
Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis
title Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis
title_full Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis
title_fullStr Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis
title_full_unstemmed Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis
title_short Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis
title_sort impact of aging on immunity in the context of covid-19, hiv, and tuberculosis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246744/
https://www.ncbi.nlm.nih.gov/pubmed/37292210
http://dx.doi.org/10.3389/fimmu.2023.1146704
work_keys_str_mv AT grifonialba impactofagingonimmunityinthecontextofcovid19hivandtuberculosis
AT alonzitonino impactofagingonimmunityinthecontextofcovid19hivandtuberculosis
AT altergalit impactofagingonimmunityinthecontextofcovid19hivandtuberculosis
AT noonandouglasmcclain impactofagingonimmunityinthecontextofcovid19hivandtuberculosis
AT landayalanl impactofagingonimmunityinthecontextofcovid19hivandtuberculosis
AT albiniadriana impactofagingonimmunityinthecontextofcovid19hivandtuberculosis
AT golettidelia impactofagingonimmunityinthecontextofcovid19hivandtuberculosis

Ejemplares similares