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Associations of VEGF Polymorphisms With Retinopathy of Prematurity

PURPOSE: This study investigated the associations between vascular endothelial growth factor (VEGF) polymorphisms and retinopathy of prematurity (ROP) risk. METHODS: Infants born prematurely at any time from 2009 to 2018 were included. Five single-nucleotide polymorphisms (SNPs) of VEGF were analyze...

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Autores principales: Ling, Xiao Chun, Kang, Eugene Yu-Chuan, Chen, Kuan-Jen, Wang, Nan-Kai, Liu, Laura, Chen, Yen-Po, Hwang, Yih-Shiou, Lai, Chi-Chun, Yang, Shun-Fa, Wu, Wei-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246755/
https://www.ncbi.nlm.nih.gov/pubmed/37272765
http://dx.doi.org/10.1167/iovs.64.7.11
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author Ling, Xiao Chun
Kang, Eugene Yu-Chuan
Chen, Kuan-Jen
Wang, Nan-Kai
Liu, Laura
Chen, Yen-Po
Hwang, Yih-Shiou
Lai, Chi-Chun
Yang, Shun-Fa
Wu, Wei-Chi
author_facet Ling, Xiao Chun
Kang, Eugene Yu-Chuan
Chen, Kuan-Jen
Wang, Nan-Kai
Liu, Laura
Chen, Yen-Po
Hwang, Yih-Shiou
Lai, Chi-Chun
Yang, Shun-Fa
Wu, Wei-Chi
author_sort Ling, Xiao Chun
collection PubMed
description PURPOSE: This study investigated the associations between vascular endothelial growth factor (VEGF) polymorphisms and retinopathy of prematurity (ROP) risk. METHODS: Infants born prematurely at any time from 2009 to 2018 were included. Five single-nucleotide polymorphisms (SNPs) of VEGF were analyzed using real-time PCR in all infants. Multivariate logistic regression was applied to model the associations between VEGF polymorphisms and ROP susceptibility, severity, and premature clinicopathologic characteristics. RESULTS: A total of 334 patients were included and categorized into three groups: those without ROP, those with mild ROP (i.e., ROP not requiring treatment), and those with severe ROP (i.e., ROP for whom treatment was indicated). Among the female patients with ROP, those with VEGF rs3025035 CT (3.231-fold; 95% confidence interval [CI], 1.238–8.431) and a combination of CT and TT genotypes (2.643-fold; 95% CI, 1.056–6.619) exhibited significantly higher risks of severe ROP compared with those with wild-type genotypes. Female ROP infants with VEGF rs3025010 C (TC + CC) alleles had a lower risk of ROP stage ≥3 (odds ratio [OR] = 0.406; 95% CI, 0.165–0.999) than those with TT homozygotes. ROP patients with the VEGF rs10434 A allele (GA + AA) exhibited higher risks of necrotizing enterocolitis (OR = 2.750; 95% CI, 1.119–6.759) and lower risk of bronchopulmonary dysplasia (OR = 0.390; 95% CI, 0.173–0.877) than those with GG homozygotes did. CONCLUSIONS: VEGF polymorphisms affect ROP risks differently in male and female infants. In female infants, VEGF rs3025035 with T alleles may predict ROP severity, and VEGF rs3025010 with C alleles may protect against severe ROP.
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spelling pubmed-102467552023-06-08 Associations of VEGF Polymorphisms With Retinopathy of Prematurity Ling, Xiao Chun Kang, Eugene Yu-Chuan Chen, Kuan-Jen Wang, Nan-Kai Liu, Laura Chen, Yen-Po Hwang, Yih-Shiou Lai, Chi-Chun Yang, Shun-Fa Wu, Wei-Chi Invest Ophthalmol Vis Sci Genetics PURPOSE: This study investigated the associations between vascular endothelial growth factor (VEGF) polymorphisms and retinopathy of prematurity (ROP) risk. METHODS: Infants born prematurely at any time from 2009 to 2018 were included. Five single-nucleotide polymorphisms (SNPs) of VEGF were analyzed using real-time PCR in all infants. Multivariate logistic regression was applied to model the associations between VEGF polymorphisms and ROP susceptibility, severity, and premature clinicopathologic characteristics. RESULTS: A total of 334 patients were included and categorized into three groups: those without ROP, those with mild ROP (i.e., ROP not requiring treatment), and those with severe ROP (i.e., ROP for whom treatment was indicated). Among the female patients with ROP, those with VEGF rs3025035 CT (3.231-fold; 95% confidence interval [CI], 1.238–8.431) and a combination of CT and TT genotypes (2.643-fold; 95% CI, 1.056–6.619) exhibited significantly higher risks of severe ROP compared with those with wild-type genotypes. Female ROP infants with VEGF rs3025010 C (TC + CC) alleles had a lower risk of ROP stage ≥3 (odds ratio [OR] = 0.406; 95% CI, 0.165–0.999) than those with TT homozygotes. ROP patients with the VEGF rs10434 A allele (GA + AA) exhibited higher risks of necrotizing enterocolitis (OR = 2.750; 95% CI, 1.119–6.759) and lower risk of bronchopulmonary dysplasia (OR = 0.390; 95% CI, 0.173–0.877) than those with GG homozygotes did. CONCLUSIONS: VEGF polymorphisms affect ROP risks differently in male and female infants. In female infants, VEGF rs3025035 with T alleles may predict ROP severity, and VEGF rs3025010 with C alleles may protect against severe ROP. The Association for Research in Vision and Ophthalmology 2023-06-05 /pmc/articles/PMC10246755/ /pubmed/37272765 http://dx.doi.org/10.1167/iovs.64.7.11 Text en Copyright 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Genetics
Ling, Xiao Chun
Kang, Eugene Yu-Chuan
Chen, Kuan-Jen
Wang, Nan-Kai
Liu, Laura
Chen, Yen-Po
Hwang, Yih-Shiou
Lai, Chi-Chun
Yang, Shun-Fa
Wu, Wei-Chi
Associations of VEGF Polymorphisms With Retinopathy of Prematurity
title Associations of VEGF Polymorphisms With Retinopathy of Prematurity
title_full Associations of VEGF Polymorphisms With Retinopathy of Prematurity
title_fullStr Associations of VEGF Polymorphisms With Retinopathy of Prematurity
title_full_unstemmed Associations of VEGF Polymorphisms With Retinopathy of Prematurity
title_short Associations of VEGF Polymorphisms With Retinopathy of Prematurity
title_sort associations of vegf polymorphisms with retinopathy of prematurity
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246755/
https://www.ncbi.nlm.nih.gov/pubmed/37272765
http://dx.doi.org/10.1167/iovs.64.7.11
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