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2MDR, a Microcomputer-Controlled Visual Stimulation Device for Psychotherapy-Like Treatments of Mice

Post-traumatic stress disorder and other mental disorders can be treated by an established psychotherapy called Eye Movement Desensitization and Reprocessing (EMDR). In EMDR, patients are confronted with traumatic memories while they are stimulated with alternating bilateral stimuli (ABS). How ABS a...

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Autores principales: Jauch, Isa, Kamm, Jan, Benn, Luca, Rettig, Lukas, Friederich, Hans-Christoph, Tesarz, Jonas, Kuner, Thomas, Wieland, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246761/
https://www.ncbi.nlm.nih.gov/pubmed/37268421
http://dx.doi.org/10.1523/ENEURO.0394-22.2023
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author Jauch, Isa
Kamm, Jan
Benn, Luca
Rettig, Lukas
Friederich, Hans-Christoph
Tesarz, Jonas
Kuner, Thomas
Wieland, Sebastian
author_facet Jauch, Isa
Kamm, Jan
Benn, Luca
Rettig, Lukas
Friederich, Hans-Christoph
Tesarz, Jonas
Kuner, Thomas
Wieland, Sebastian
author_sort Jauch, Isa
collection PubMed
description Post-traumatic stress disorder and other mental disorders can be treated by an established psychotherapy called Eye Movement Desensitization and Reprocessing (EMDR). In EMDR, patients are confronted with traumatic memories while they are stimulated with alternating bilateral stimuli (ABS). How ABS affects the brain and whether ABS could be adapted to different patients or mental disorders is unknown. Interestingly, ABS reduced conditioned fear in mice. Yet, an approach to systematically test complex visual stimuli and compare respective differences in emotional processing based on semiautomated/automated behavioral analysis is lacking. We developed 2MDR (MultiModal Visual Stimulation to Desensitize Rodents), a novel, open-source, low-cost, customizable device that can be integrated in and transistor–transistor logic (TTL) controlled by commercial rodent behavioral setups. 2MDR allows the design and precise steering of multimodal visual stimuli in the head direction of freely moving mice. Optimized videography allows semiautomatic analysis of rodent behavior during visual stimulation. Detailed building, integration, and treatment instructions along with open-source software provide easy access for inexperienced users. Using 2MDR, we confirmed that EMDR-like ABS persistently improves fear extinction in mice and showed for the first time that ABS-mediated anxiolytic effects strongly depend on physical stimulus properties such as ABS brightness. 2MDR not only enables researchers to interfere with mouse behavior in an EMDR-like setting, but also demonstrates that visual stimuli can be used as a noninvasive brain stimulation to differentially alter emotional processing in mice.
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spelling pubmed-102467612023-06-08 2MDR, a Microcomputer-Controlled Visual Stimulation Device for Psychotherapy-Like Treatments of Mice Jauch, Isa Kamm, Jan Benn, Luca Rettig, Lukas Friederich, Hans-Christoph Tesarz, Jonas Kuner, Thomas Wieland, Sebastian eNeuro Open Source Tools and Methods Post-traumatic stress disorder and other mental disorders can be treated by an established psychotherapy called Eye Movement Desensitization and Reprocessing (EMDR). In EMDR, patients are confronted with traumatic memories while they are stimulated with alternating bilateral stimuli (ABS). How ABS affects the brain and whether ABS could be adapted to different patients or mental disorders is unknown. Interestingly, ABS reduced conditioned fear in mice. Yet, an approach to systematically test complex visual stimuli and compare respective differences in emotional processing based on semiautomated/automated behavioral analysis is lacking. We developed 2MDR (MultiModal Visual Stimulation to Desensitize Rodents), a novel, open-source, low-cost, customizable device that can be integrated in and transistor–transistor logic (TTL) controlled by commercial rodent behavioral setups. 2MDR allows the design and precise steering of multimodal visual stimuli in the head direction of freely moving mice. Optimized videography allows semiautomatic analysis of rodent behavior during visual stimulation. Detailed building, integration, and treatment instructions along with open-source software provide easy access for inexperienced users. Using 2MDR, we confirmed that EMDR-like ABS persistently improves fear extinction in mice and showed for the first time that ABS-mediated anxiolytic effects strongly depend on physical stimulus properties such as ABS brightness. 2MDR not only enables researchers to interfere with mouse behavior in an EMDR-like setting, but also demonstrates that visual stimuli can be used as a noninvasive brain stimulation to differentially alter emotional processing in mice. Society for Neuroscience 2023-06-02 /pmc/articles/PMC10246761/ /pubmed/37268421 http://dx.doi.org/10.1523/ENEURO.0394-22.2023 Text en Copyright © 2023 Jauch et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Open Source Tools and Methods
Jauch, Isa
Kamm, Jan
Benn, Luca
Rettig, Lukas
Friederich, Hans-Christoph
Tesarz, Jonas
Kuner, Thomas
Wieland, Sebastian
2MDR, a Microcomputer-Controlled Visual Stimulation Device for Psychotherapy-Like Treatments of Mice
title 2MDR, a Microcomputer-Controlled Visual Stimulation Device for Psychotherapy-Like Treatments of Mice
title_full 2MDR, a Microcomputer-Controlled Visual Stimulation Device for Psychotherapy-Like Treatments of Mice
title_fullStr 2MDR, a Microcomputer-Controlled Visual Stimulation Device for Psychotherapy-Like Treatments of Mice
title_full_unstemmed 2MDR, a Microcomputer-Controlled Visual Stimulation Device for Psychotherapy-Like Treatments of Mice
title_short 2MDR, a Microcomputer-Controlled Visual Stimulation Device for Psychotherapy-Like Treatments of Mice
title_sort 2mdr, a microcomputer-controlled visual stimulation device for psychotherapy-like treatments of mice
topic Open Source Tools and Methods
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246761/
https://www.ncbi.nlm.nih.gov/pubmed/37268421
http://dx.doi.org/10.1523/ENEURO.0394-22.2023
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