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Associations of adenovirus-reactive immunoglobulins with atrial fibrillation and body mass index

Adenovirus (AdV) has been suggested to be involved in pathogenesis of atrial fibrillation (AF). We aimed to evaluate an association between AdV-specific immunoglobulins G in the serum (AdV-IgG) and AF. The present case-control study comprised two cohorts, including cohort 1 of patients with AF and c...

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Autores principales: Gumanova, Nadezhda G., Zlobina, Polina D., Bogdanova, Natalya L., Brutyan, Hakob A., Kalemberg, Elena N., Metelskaya, Victoria A., Davtyan, Karapet V., Drapkina, Oksana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246773/
https://www.ncbi.nlm.nih.gov/pubmed/37293276
http://dx.doi.org/10.3389/fcvm.2023.1190051
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author Gumanova, Nadezhda G.
Zlobina, Polina D.
Bogdanova, Natalya L.
Brutyan, Hakob A.
Kalemberg, Elena N.
Metelskaya, Victoria A.
Davtyan, Karapet V.
Drapkina, Oksana M.
author_facet Gumanova, Nadezhda G.
Zlobina, Polina D.
Bogdanova, Natalya L.
Brutyan, Hakob A.
Kalemberg, Elena N.
Metelskaya, Victoria A.
Davtyan, Karapet V.
Drapkina, Oksana M.
author_sort Gumanova, Nadezhda G.
collection PubMed
description Adenovirus (AdV) has been suggested to be involved in pathogenesis of atrial fibrillation (AF). We aimed to evaluate an association between AdV-specific immunoglobulins G in the serum (AdV-IgG) and AF. The present case-control study comprised two cohorts, including cohort 1 of patients with AF and cohort 2 of asymptomatic subjects. Initially, two groups, MA and MB, were selected from the cohorts 1 and 2, respectively, for serum proteome profiling using an antibody microarray to identify possible relevant protein targets. The data of microarray analysis indicated a possible overall increase in the total adenovirus signals in the group MA vs. group MB, suggesting potential relevance of adenoviral infection to AF. Then, the groups A (with AF) and B (control) were selected from the cohorts 1 and 2, respectively, to assay the presence and levels of AdV-IgG- by ELSA. The prevalence of AdV-IgG-positive status demonstrated a 2-fold increase in the group A (AF) compared with that in the group B (asymptomatic subjects); odds ratio 2.06 (95%CI: 1.11–3.84; P = 0.02). The prevalence of obesity demonstrated an approximately 3-fold increase in AdV-IgG-positive patients of the group A compared with that in AdV-IgG-negative patients of the same group A (odds ratio 2.7; 95% CI: 1.02–7.1; P = 0.04). Thus, AdV-IgG-positive reactivity was independently associated with AF, and AF was independently associated with BMI, indicating that adenoviral infection may be a possible etiological factor for AF.
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spelling pubmed-102467732023-06-08 Associations of adenovirus-reactive immunoglobulins with atrial fibrillation and body mass index Gumanova, Nadezhda G. Zlobina, Polina D. Bogdanova, Natalya L. Brutyan, Hakob A. Kalemberg, Elena N. Metelskaya, Victoria A. Davtyan, Karapet V. Drapkina, Oksana M. Front Cardiovasc Med Cardiovascular Medicine Adenovirus (AdV) has been suggested to be involved in pathogenesis of atrial fibrillation (AF). We aimed to evaluate an association between AdV-specific immunoglobulins G in the serum (AdV-IgG) and AF. The present case-control study comprised two cohorts, including cohort 1 of patients with AF and cohort 2 of asymptomatic subjects. Initially, two groups, MA and MB, were selected from the cohorts 1 and 2, respectively, for serum proteome profiling using an antibody microarray to identify possible relevant protein targets. The data of microarray analysis indicated a possible overall increase in the total adenovirus signals in the group MA vs. group MB, suggesting potential relevance of adenoviral infection to AF. Then, the groups A (with AF) and B (control) were selected from the cohorts 1 and 2, respectively, to assay the presence and levels of AdV-IgG- by ELSA. The prevalence of AdV-IgG-positive status demonstrated a 2-fold increase in the group A (AF) compared with that in the group B (asymptomatic subjects); odds ratio 2.06 (95%CI: 1.11–3.84; P = 0.02). The prevalence of obesity demonstrated an approximately 3-fold increase in AdV-IgG-positive patients of the group A compared with that in AdV-IgG-negative patients of the same group A (odds ratio 2.7; 95% CI: 1.02–7.1; P = 0.04). Thus, AdV-IgG-positive reactivity was independently associated with AF, and AF was independently associated with BMI, indicating that adenoviral infection may be a possible etiological factor for AF. Frontiers Media S.A. 2023-05-24 /pmc/articles/PMC10246773/ /pubmed/37293276 http://dx.doi.org/10.3389/fcvm.2023.1190051 Text en ©2023 Gumanova, Zlobina, Bogdanova, Brutyan, Kalemberg, Metelskaya, Davtyan and Drapkina. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Gumanova, Nadezhda G.
Zlobina, Polina D.
Bogdanova, Natalya L.
Brutyan, Hakob A.
Kalemberg, Elena N.
Metelskaya, Victoria A.
Davtyan, Karapet V.
Drapkina, Oksana M.
Associations of adenovirus-reactive immunoglobulins with atrial fibrillation and body mass index
title Associations of adenovirus-reactive immunoglobulins with atrial fibrillation and body mass index
title_full Associations of adenovirus-reactive immunoglobulins with atrial fibrillation and body mass index
title_fullStr Associations of adenovirus-reactive immunoglobulins with atrial fibrillation and body mass index
title_full_unstemmed Associations of adenovirus-reactive immunoglobulins with atrial fibrillation and body mass index
title_short Associations of adenovirus-reactive immunoglobulins with atrial fibrillation and body mass index
title_sort associations of adenovirus-reactive immunoglobulins with atrial fibrillation and body mass index
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246773/
https://www.ncbi.nlm.nih.gov/pubmed/37293276
http://dx.doi.org/10.3389/fcvm.2023.1190051
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