Trace quantification of GL-V9 and its glucuronide metabolites (5-O-glucuronide GL-V9) in Beagle dog plasma by UPLC–MS/MS and its application to a pharmacokinetic study

GL-V9, a new synthetic flavonoid derived from wogonin, has shown beneficial biological functions. In this study, accurate and sensitive UPLC–MS/MS methods were developed and validated for the quantification of GL-V9 and its glucuronide metabolite (5-O-glucuronide GL-V9) in Beagle dog plasma. The chr...

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Detalles Bibliográficos
Autores principales: Zhang, Xuefeng, Liu, Guanlan, Sang, Zechun, Guo, Qinglong, Zhou, Yuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246788/
https://www.ncbi.nlm.nih.gov/pubmed/37285365
http://dx.doi.org/10.1371/journal.pone.0286467

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