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The impact of population screening for cardiovascular disease on quality of life

AIMS: To examine the impact of population screening–generated events on quality of life: invitation, positive test result, initiation of preventive medication, enrolment in follow-up at the surgical department, and preventive surgical repair. METHODS AND RESULTS: A difference-in-difference design ba...

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Autores principales: Søgaard, Rikke, Diederichsen, Axel, Lindholt, Jes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246813/
https://www.ncbi.nlm.nih.gov/pubmed/37293138
http://dx.doi.org/10.1093/ehjopen/oead055
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author Søgaard, Rikke
Diederichsen, Axel
Lindholt, Jes
author_facet Søgaard, Rikke
Diederichsen, Axel
Lindholt, Jes
author_sort Søgaard, Rikke
collection PubMed
description AIMS: To examine the impact of population screening–generated events on quality of life: invitation, positive test result, initiation of preventive medication, enrolment in follow-up at the surgical department, and preventive surgical repair. METHODS AND RESULTS: A difference-in-difference design based on data collected alongside two randomized controlled trials where general population men were randomized to screening for cardiovascular disease or to no screening. Repeated measurements of health-related quality of life (HRQoL) were conducted up to 3 years after inclusion using all relevant scales of the EuroQol instrument: the anxiety/depression dimension, the EuroQol 5-dimension profile index (using Danish preference weights), and the visual analogue scale for global health. We compare the mean change scores from before to after events for groups experiencing vs. not experiencing the events. Propensity score matching is additionally used to provide both unmatched and matched results. Invitees reported to be marginally better off than non-invitees on all scales of the EuroQol. For events of receiving the test result, initiating preventive medication, being enrolled in surveillance, and undergoing surgical repair, we observed no impact on overall HRQoL but a minor impact of being enrolled in surveillance on emotional distress, which did not persist after matching. CONCLUSION: The often-claimed detrimental consequences of screening to HRQoL could not be generally confirmed. Amongst the screening events assessed, only two possible consequences were revealed: a reassurance effect after a negative screening test and a minor negative impact to emotional distress of being enrolled in surveillance that did not spill over to overall HRQoL.
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spelling pubmed-102468132023-06-08 The impact of population screening for cardiovascular disease on quality of life Søgaard, Rikke Diederichsen, Axel Lindholt, Jes Eur Heart J Open Original Article AIMS: To examine the impact of population screening–generated events on quality of life: invitation, positive test result, initiation of preventive medication, enrolment in follow-up at the surgical department, and preventive surgical repair. METHODS AND RESULTS: A difference-in-difference design based on data collected alongside two randomized controlled trials where general population men were randomized to screening for cardiovascular disease or to no screening. Repeated measurements of health-related quality of life (HRQoL) were conducted up to 3 years after inclusion using all relevant scales of the EuroQol instrument: the anxiety/depression dimension, the EuroQol 5-dimension profile index (using Danish preference weights), and the visual analogue scale for global health. We compare the mean change scores from before to after events for groups experiencing vs. not experiencing the events. Propensity score matching is additionally used to provide both unmatched and matched results. Invitees reported to be marginally better off than non-invitees on all scales of the EuroQol. For events of receiving the test result, initiating preventive medication, being enrolled in surveillance, and undergoing surgical repair, we observed no impact on overall HRQoL but a minor impact of being enrolled in surveillance on emotional distress, which did not persist after matching. CONCLUSION: The often-claimed detrimental consequences of screening to HRQoL could not be generally confirmed. Amongst the screening events assessed, only two possible consequences were revealed: a reassurance effect after a negative screening test and a minor negative impact to emotional distress of being enrolled in surveillance that did not spill over to overall HRQoL. Oxford University Press 2023-05-23 /pmc/articles/PMC10246813/ /pubmed/37293138 http://dx.doi.org/10.1093/ehjopen/oead055 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Søgaard, Rikke
Diederichsen, Axel
Lindholt, Jes
The impact of population screening for cardiovascular disease on quality of life
title The impact of population screening for cardiovascular disease on quality of life
title_full The impact of population screening for cardiovascular disease on quality of life
title_fullStr The impact of population screening for cardiovascular disease on quality of life
title_full_unstemmed The impact of population screening for cardiovascular disease on quality of life
title_short The impact of population screening for cardiovascular disease on quality of life
title_sort impact of population screening for cardiovascular disease on quality of life
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246813/
https://www.ncbi.nlm.nih.gov/pubmed/37293138
http://dx.doi.org/10.1093/ehjopen/oead055
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