The effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing

The clinical efficacy of ESWT in treating bone non union has been widely recognized, but the biological mechanism of ESWT promoting bone non union healing is still unclear. ESWT can make old callus micro fracture through mechanical conduction, form subperiosteal hematoma, promote the release of bioa...

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Detalles Bibliográficos
Autores principales: Lv, Fuxian, Li, Zhenlan, Jing, Yuling, Sun, Liyuan, Li, Zhiwei, Duan, Haoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246855/
https://www.ncbi.nlm.nih.gov/pubmed/37293486
http://dx.doi.org/10.3389/fendo.2023.1188297
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author Lv, Fuxian
Li, Zhenlan
Jing, Yuling
Sun, Liyuan
Li, Zhiwei
Duan, Haoyang
author_facet Lv, Fuxian
Li, Zhenlan
Jing, Yuling
Sun, Liyuan
Li, Zhiwei
Duan, Haoyang
author_sort Lv, Fuxian
collection PubMed
description The clinical efficacy of ESWT in treating bone non union has been widely recognized, but the biological mechanism of ESWT promoting bone non union healing is still unclear. ESWT can make old callus micro fracture through mechanical conduction, form subperiosteal hematoma, promote the release of bioactive factors, reactivate the fracture healing mechanism, rebalance the activities of osteoblasts and osteoclast, promote the angiogenesis of fracture site, and accelerate the healing of bone nonunion.Over recent years, great efforts have been made by both scientists and clinicians to explore the underlying mechanism behind the healing effect of ESWT on bone fractures. In this review, we introduced the growth factors during osteogenesis induced by ESWT hoping to provide new insights in the clinical use of ESWT.
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spelling pubmed-102468552023-06-08 The effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing Lv, Fuxian Li, Zhenlan Jing, Yuling Sun, Liyuan Li, Zhiwei Duan, Haoyang Front Endocrinol (Lausanne) Endocrinology The clinical efficacy of ESWT in treating bone non union has been widely recognized, but the biological mechanism of ESWT promoting bone non union healing is still unclear. ESWT can make old callus micro fracture through mechanical conduction, form subperiosteal hematoma, promote the release of bioactive factors, reactivate the fracture healing mechanism, rebalance the activities of osteoblasts and osteoclast, promote the angiogenesis of fracture site, and accelerate the healing of bone nonunion.Over recent years, great efforts have been made by both scientists and clinicians to explore the underlying mechanism behind the healing effect of ESWT on bone fractures. In this review, we introduced the growth factors during osteogenesis induced by ESWT hoping to provide new insights in the clinical use of ESWT. Frontiers Media S.A. 2023-05-24 /pmc/articles/PMC10246855/ /pubmed/37293486 http://dx.doi.org/10.3389/fendo.2023.1188297 Text en Copyright © 2023 Lv, Li, Jing, Sun, Li and Duan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Lv, Fuxian
Li, Zhenlan
Jing, Yuling
Sun, Liyuan
Li, Zhiwei
Duan, Haoyang
The effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing
title The effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing
title_full The effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing
title_fullStr The effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing
title_full_unstemmed The effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing
title_short The effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing
title_sort effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246855/
https://www.ncbi.nlm.nih.gov/pubmed/37293486
http://dx.doi.org/10.3389/fendo.2023.1188297
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