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The Novel DNA Binding Mechanism of Ridinilazole, a Precision Clostridiodes difficile Antibiotic

Clostridioides difficile infection (CDI) causes substantial morbidity and mortality worldwide with limited antibiotic treatment options. Ridinilazole is a precision bisbenzimidazole antibiotic being developed to treat CDI and reduce unacceptably high rates of infection recurrence in patients. Althou...

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Detalles Bibliográficos
Autores principales:	Mason, Clive S., Avis, Tim, Hu, Chenlin, Nagalingam, Nabeetha, Mudaliar, Manikhandan, Coward, Chris, Begum, Khurshida, Gajewski, Kathleen, Alam, M. Jahangir, Bassères, Eugenie, Moss, Stephen, Reich, Stefanie, Duperchy, Esther, Fox, Keith R., Garey, Kevin W., Powell, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Mechanisms of Action: Physiological Effects
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246881/ https://www.ncbi.nlm.nih.gov/pubmed/37093023 http://dx.doi.org/10.1128/aac.01563-22

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