SARS-CoV-2 targets the liver and manipulates glucose metabolism

A recent publication by Barreto and colleagues showed that SARS-CoV-2 directly triggers hyperglycemia by infecting hepatocytes and inducing phosphoenolpyruvate carboxykinase (PEPCK)-dependent gluconeogenesis. Here, we discuss the biological importance of these findings, including the hepatic tropism...

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Detalles Bibliográficos
Autores principales: Pirola, Carlos J., Sookoian, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247144/
https://www.ncbi.nlm.nih.gov/pubmed/37330366
http://dx.doi.org/10.1016/j.molmed.2023.06.001
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author Pirola, Carlos J.
Sookoian, Silvia
author_facet Pirola, Carlos J.
Sookoian, Silvia
author_sort Pirola, Carlos J.
collection PubMed
description A recent publication by Barreto and colleagues showed that SARS-CoV-2 directly triggers hyperglycemia by infecting hepatocytes and inducing phosphoenolpyruvate carboxykinase (PEPCK)-dependent gluconeogenesis. Here, we discuss the biological importance of these findings, including the hepatic tropism of SARS-CoV-2. We also comment on the clinical implications of the bidirectional connection between COVID-19 and noncommunicable diseases.
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spelling pubmed-102471442023-06-08 SARS-CoV-2 targets the liver and manipulates glucose metabolism Pirola, Carlos J. Sookoian, Silvia Trends Mol Med Spotlight A recent publication by Barreto and colleagues showed that SARS-CoV-2 directly triggers hyperglycemia by infecting hepatocytes and inducing phosphoenolpyruvate carboxykinase (PEPCK)-dependent gluconeogenesis. Here, we discuss the biological importance of these findings, including the hepatic tropism of SARS-CoV-2. We also comment on the clinical implications of the bidirectional connection between COVID-19 and noncommunicable diseases. Elsevier Ltd. 2023-06-07 /pmc/articles/PMC10247144/ /pubmed/37330366 http://dx.doi.org/10.1016/j.molmed.2023.06.001 Text en © 2023 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Spotlight
Pirola, Carlos J.
Sookoian, Silvia
SARS-CoV-2 targets the liver and manipulates glucose metabolism
title SARS-CoV-2 targets the liver and manipulates glucose metabolism
title_full SARS-CoV-2 targets the liver and manipulates glucose metabolism
title_fullStr SARS-CoV-2 targets the liver and manipulates glucose metabolism
title_full_unstemmed SARS-CoV-2 targets the liver and manipulates glucose metabolism
title_short SARS-CoV-2 targets the liver and manipulates glucose metabolism
title_sort sars-cov-2 targets the liver and manipulates glucose metabolism
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247144/
https://www.ncbi.nlm.nih.gov/pubmed/37330366
http://dx.doi.org/10.1016/j.molmed.2023.06.001
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