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One week pre-operative oral antibiotics for percutaneous nephrolithotomy reduce risk of infection: a systematic review and meta-analysis

PURPOSE: The aim of this meta-analysis is to assess the efficacy of extended dose of preoperative antibiotics to reduce infectious risk in patients undergoing percutaneous nephrolithotomy (PCNL). MATERIALS AND METHODS: A literature search for prospective case-control studies or randomized controlled...

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Autores principales: Danilovic, Alexandre, Talizin, Thalita Bento, Torricelli, Fabio Cesar Miranda, Marchini, Giovanni S., Batagello, Carlos, Vicentini, Fabio C., Nahas, Willaim C., Mazzucchi, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Urologia 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247227/
https://www.ncbi.nlm.nih.gov/pubmed/36515617
http://dx.doi.org/10.1590/S1677-5538.IBJU.2022.0544
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author Danilovic, Alexandre
Talizin, Thalita Bento
Torricelli, Fabio Cesar Miranda
Marchini, Giovanni S.
Batagello, Carlos
Vicentini, Fabio C.
Nahas, Willaim C.
Mazzucchi, Eduardo
author_facet Danilovic, Alexandre
Talizin, Thalita Bento
Torricelli, Fabio Cesar Miranda
Marchini, Giovanni S.
Batagello, Carlos
Vicentini, Fabio C.
Nahas, Willaim C.
Mazzucchi, Eduardo
author_sort Danilovic, Alexandre
collection PubMed
description PURPOSE: The aim of this meta-analysis is to assess the efficacy of extended dose of preoperative antibiotics to reduce infectious risk in patients undergoing percutaneous nephrolithotomy (PCNL). MATERIALS AND METHODS: A literature search for prospective case-control studies or randomized controlled trials was done. PICO framework was used. Population: adult patients that underwent to PCNL; Intervention: extended dose preoperative antibiotic prophylaxis before PCNL; Control: short dose preoperative antibiotic prophylaxis before PCNL; and Outcome: systemic inflammatory response syndrome (SIRS) or sepsis, fever after PCNL and positive intraoperative urine and stone culture. This meta-analysis was registered in PROSPERO database under the number: CRD42022359589. RESULTS: Three RCT and two prospective studies (475 patients) were included. SIRS/sepsis outcome was retrieved from all studies included. Seven days preoperative oral antibiotics for PCNL was a protective factor for developing SIRS/sepsis (OR 0.366, 95% CI 0.234 - 0.527, p < 0.001). There was no statistical association between seven-day use of antibiotics and fever (OR 0.592, 95% CI 0.147 – 2.388, p = 0.462). Patients who received seven days preoperative antibiotics had lower positive intraoperative urine culture (OR 0.284, 95% CI 0.120 – 0.674, p = 0.004) and stone culture (OR 0.351, 95% CI 0.185 – 0.663, p = 0.001) than the control group. CONCLUSION: one week of prophylactic oral antibiotics based on local bacterial sensitivity pattern plus a dose of intravenous antibiotics at the time of surgery in patients undergoing PCNL reduces the risk of infection.
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spelling pubmed-102472272023-06-08 One week pre-operative oral antibiotics for percutaneous nephrolithotomy reduce risk of infection: a systematic review and meta-analysis Danilovic, Alexandre Talizin, Thalita Bento Torricelli, Fabio Cesar Miranda Marchini, Giovanni S. Batagello, Carlos Vicentini, Fabio C. Nahas, Willaim C. Mazzucchi, Eduardo Int Braz J Urol Review Article PURPOSE: The aim of this meta-analysis is to assess the efficacy of extended dose of preoperative antibiotics to reduce infectious risk in patients undergoing percutaneous nephrolithotomy (PCNL). MATERIALS AND METHODS: A literature search for prospective case-control studies or randomized controlled trials was done. PICO framework was used. Population: adult patients that underwent to PCNL; Intervention: extended dose preoperative antibiotic prophylaxis before PCNL; Control: short dose preoperative antibiotic prophylaxis before PCNL; and Outcome: systemic inflammatory response syndrome (SIRS) or sepsis, fever after PCNL and positive intraoperative urine and stone culture. This meta-analysis was registered in PROSPERO database under the number: CRD42022359589. RESULTS: Three RCT and two prospective studies (475 patients) were included. SIRS/sepsis outcome was retrieved from all studies included. Seven days preoperative oral antibiotics for PCNL was a protective factor for developing SIRS/sepsis (OR 0.366, 95% CI 0.234 - 0.527, p < 0.001). There was no statistical association between seven-day use of antibiotics and fever (OR 0.592, 95% CI 0.147 – 2.388, p = 0.462). Patients who received seven days preoperative antibiotics had lower positive intraoperative urine culture (OR 0.284, 95% CI 0.120 – 0.674, p = 0.004) and stone culture (OR 0.351, 95% CI 0.185 – 0.663, p = 0.001) than the control group. CONCLUSION: one week of prophylactic oral antibiotics based on local bacterial sensitivity pattern plus a dose of intravenous antibiotics at the time of surgery in patients undergoing PCNL reduces the risk of infection. Sociedade Brasileira de Urologia 2022-12-15 /pmc/articles/PMC10247227/ /pubmed/36515617 http://dx.doi.org/10.1590/S1677-5538.IBJU.2022.0544 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Danilovic, Alexandre
Talizin, Thalita Bento
Torricelli, Fabio Cesar Miranda
Marchini, Giovanni S.
Batagello, Carlos
Vicentini, Fabio C.
Nahas, Willaim C.
Mazzucchi, Eduardo
One week pre-operative oral antibiotics for percutaneous nephrolithotomy reduce risk of infection: a systematic review and meta-analysis
title One week pre-operative oral antibiotics for percutaneous nephrolithotomy reduce risk of infection: a systematic review and meta-analysis
title_full One week pre-operative oral antibiotics for percutaneous nephrolithotomy reduce risk of infection: a systematic review and meta-analysis
title_fullStr One week pre-operative oral antibiotics for percutaneous nephrolithotomy reduce risk of infection: a systematic review and meta-analysis
title_full_unstemmed One week pre-operative oral antibiotics for percutaneous nephrolithotomy reduce risk of infection: a systematic review and meta-analysis
title_short One week pre-operative oral antibiotics for percutaneous nephrolithotomy reduce risk of infection: a systematic review and meta-analysis
title_sort one week pre-operative oral antibiotics for percutaneous nephrolithotomy reduce risk of infection: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247227/
https://www.ncbi.nlm.nih.gov/pubmed/36515617
http://dx.doi.org/10.1590/S1677-5538.IBJU.2022.0544
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